130106-00-2Relevant articles and documents
Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors
Wang, Mingliang,Fang, Yanjia,Gu, Shoulai,Chen, Fangfang,Zhu, Zhengjiang,Sun, Xun,Zhu, Jidong
, p. 157 - 172 (2017)
The inhibition of CYP17 to block androgen biosynthesis is a well validated strategy for the treatment of prostate cancer. Herein we reported the design, synthesis and structure–activity relationship (SAR) study for a series of novel 1,2,3,4- tetrahydroben
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis
Chen, Tian,Benmohamed, Radhia,Arvanites, Anthony C.,Ranaivo, Hantamalala Ralay,Morimoto, Richard I.,Ferrante, Robert J.,Watterson, D. Martin,Kirsch, Donald R.,Silverman, Richard B.
experimental part, p. 613 - 622 (2011/03/17)
Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. Mutations in copper/zinc superoxide dismutase 1 (SOD1) have been implicated in the pathophysiology of this disease. Using a high-throughput screening assa
5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa
Qiao, Jennifer X.,Cheng, Xuhong,Modi, Dilip P.,Rossi, Karen A.,Luettgen, Joseph M.,Knabb, Robert M.,Jadhav, Prabhakar K.,Wexler, Ruth R.
, p. 29 - 35 (2007/10/03)
Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa potency and equal or slightly better selectivity relative to factor Xa. Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa activity and equal or slightly better selectivity relative to factor Xa.
