130120-68-2Relevant articles and documents
Chemical process for the preparation of purine derivatives
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, (2008/06/13)
A process for the preparation of a compound of formula (I) STR1 which process comprises reacting a compound of formula (II): STR2 wherein the amino group is optionally protected, with a side chain intermediate of formula (III): STR3 wherein Q is a leaving group, Rx and Ry are protected hydroxymethyl or acyloxymethyl, or group(s) convertible to hydroxymethyl or acyloxymethyl; and Rz is hydrogen or a group convertible thereto; and thereafter converting the 6- and 8- chloro substituents to hydrogen by means of reduction; converting Rx and Ry when other than hydroxymethyl or acyloxymethyl, to hydroxymethyl or acyloxymethyl, optionally converting Rx /Ry hydroxymethyl to acyloxymethyl or vice versa, deprotecting the 2-amino group where necessary and converting Rz, (when other than hydrogen) to hydrogen; and optionally forming a pharmaceutically acceptable salt thereof.
