130120-81-9

Basic information

• Product Name: 4-(2-methoxyphenyl)-2-<<4(5)-imidazolyl>methyl>thiazole hydrochloride
• Synonyms: 4-(2-methoxyphenyl)-2-<<4(5)-imidazolyl>methyl>thiazole hydrochloride
• CAS NO: 130120-81-9
• Molecular Weight: 307.804
• Mol File: 130120-81-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-methoxyphenyl)-2-<<4(5)-imidazolyl>methyl>thiazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-methoxyphenyl)-2-<<4(5)-imidazolyl>methyl>thiazole hydrochloride(130120-81-9)
• EPA Substance Registry System: 4-(2-methoxyphenyl)-2-<<4(5)-imidazolyl>methyl>thiazole hydrochloride(130120-81-9)

Safety Data

• Hazardous Substances Data: 130120-81-9(Hazardous Substances Data)

Upstream product

• 31949-21-0 bromomethyl 2-methoxyphenyl ketone 
• 124583-56-8 4⁽⁵⁾-(2-amino-2-thioxoethyl)imidazole hydrochloride 

Relevant articles and documents

Thiazole as a Carbonyl Bioisostere. A Novel Class of Highly Potent and Selective 5-HT3 Receptor Antagonists

A novel structural class of highly potent and selective 5-HT3 receptor antagonists is described.The compounds in this new series contain a thiazole moiety linking an aromatic group and a nitrogen-containing basic region; the thiazole group appears to be acting as a carbonyl bioisostere in this system.An optimized member of this series, 4-(2-methoxyphenyl)-2-methyl>thiazole (5), exhibits oral activity in the Bezold-Jarisch reflex paradigm comparable to or better than the standard agents ondansetron (1) and ICS-205-930 (2).Several of the structure-activity relationships are rationalized in terms of a computer pharmacophore model for 5-HT3 receptor binding.