1301760-11-1 Usage
Description
(2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride is a complex organic compound featuring a tetrahydro-1H-pyrrole ring with a carboxylic acid and a 2-methylbutanoic anhydride group. The presence of a tert-Butoxycarbonyl (Boc) protecting group suggests its utility in peptide synthesis or as an intermediate in organic chemistry. The (2R) stereochemistry at the carbon center indicates a specific spatial arrangement, which may be crucial for its reactivity and applications.
Uses
Used in Organic Synthesis:
(2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride serves as a versatile intermediate in organic synthesis, particularly for the creation of complex molecular structures. Its unique combination of functional groups allows for a variety of chemical reactions, making it a valuable building block for the development of new compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, this compound is utilized as a precursor in the synthesis of potential drug candidates. Its specific stereochemistry and functional groups may contribute to the design of molecules with targeted biological activities, such as enzyme inhibition or receptor binding.
Used in Peptide Synthesis:
The presence of the Boc protecting group in (2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride makes it suitable for use in peptide synthesis. The Boc group can be selectively removed under mild conditions, allowing for the stepwise assembly of peptide chains with precise control over the sequence and structure.
Overall, (2R)-1-(tert-Butoxycarbonyl)tetrahydro-1H-pyrrole-2-carboxylic 2-methylbutanoic anhydride is a specialized chemical with applications in various fields, including organic synthesis, pharmaceutical research, and peptide chemistry, due to its unique structural features and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1301760-11-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,1,7,6 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1301760-11:
(9*1)+(8*3)+(7*0)+(6*1)+(5*7)+(4*6)+(3*0)+(2*1)+(1*1)=101
101 % 10 = 1
So 1301760-11-1 is a valid CAS Registry Number.
1301760-11-1Relevant articles and documents
Synthesis and biological evaluation of potential 5-HT7 receptor PET radiotracers
Andries, Julien,Lemoine, Laetitia,Le Bars, Didier,Zimmer, Luc,Billard, Thierry
, p. 3455 - 3461 (2011)
Brain serotonin 7 receptor (5-HT7) is involved in several mood disorders and drug candidates targeting this subtype are currently in development. Positron emission tomography (PET) is a molecular imaging modality offering great promise for accelerating the process from preclinical discovery to clinical phases. As no PET radiopharmaceutical has yet been used successfully to study the 5-HT7 receptor in vivo, our objective is to develop the first 5-HT7 fluorine-18 labeled radiotracer. Four structural analogs of SB269970, a specific 5-HT7 receptor antagonist, divided in FP3 series and FPMP series were synthesized. Their antagonist effects were investigated by cellular functional assay. Nitro-precursors of these analogs were radiolabeled via a [18F-]nucleophilic substitution and in vitro autoradiographies were performed in rat brain. Chemical and radiochemical purities of fluorine radiotracers were >99% with specific activities in 40-129 GBq/μmole range. The four derivates presented antagonism potencies toward 5-HT7 receptors (pKB) between 7.8 and 8.8. The four PET radiotracers had suitable characteristic for 5-HT7 receptor probing in vitro even if the FP3 series seemed to be more specific for this receptor. These results encourage us to pursue in vivo studies.
