130210-32-1

Basic information

• Product Name: N-(4-HYDROXYPHENYLACETYL)SPERMINE
• Synonyms: N-(4-HYDROXYPHENYLACETYL)SPERMINE;N-(N-(4-HYDROXYPHENYLACETYL)-3-AMINOPROPYL)-(N'-3-AMINOPROPYL)-1,4-BUTANEDIAMINE
• CAS NO: 130210-32-1
• Molecular Formula: C18H32N4O2
• Molecular Weight: 336.47
• Product Categories: Glutamate receptor
• Mol File: 130210-32-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Desiccate at -20°C
• CAS DataBase Reference: N-(4-HYDROXYPHENYLACETYL)SPERMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-HYDROXYPHENYLACETYL)SPERMINE(130210-32-1)
• EPA Substance Registry System: N-(4-HYDROXYPHENYLACETYL)SPERMINE(130210-32-1)

Safety Data

• Hazardous Substances Data: 130210-32-1(Hazardous Substances Data)

Usage

Description

N-(4-Hydroxyphenylacetyl)spermine is a wasp toxin analog of PhTX-433, characterized by its potent glutamate antagonistic properties. N-(4-HYDROXYPHENYLACETYL)SPERMINE is derived from the venom of the wasp and has been studied for its potential applications in various fields due to its unique biochemical characteristics.

Uses

Used in Pharmaceutical Industry:
N-(4-Hydroxyphenylacetyl)spermine is used as a pharmaceutical agent for its glutamate antagonistic activity. N-(4-HYDROXYPHENYLACETYL)SPERMINE's ability to modulate glutamate signaling pathways makes it a promising candidate for the development of drugs targeting neurological disorders associated with glutamate dysregulation, such as Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions.
Used in Research Applications:
In the field of scientific research, N-(4-Hydroxyphenylacetyl)spermine serves as a valuable tool for studying the role of glutamate in the central nervous system. Its potent antagonistic effects allow researchers to investigate the mechanisms of glutamate-mediated neurotransmission and develop a deeper understanding of the underlying processes in various neurological conditions.
Used in Drug Development:
N-(4-Hydroxyphenylacetyl)spermine is utilized in the development of novel therapeutic agents targeting the glutamatergic system. Its unique structure and function provide a foundation for the design of new drugs with improved efficacy, selectivity, and safety profiles. N-(4-HYDROXYPHENYLACETYL)SPERMINE may also be used in combination with other drugs to enhance their therapeutic effects or overcome resistance in certain conditions.

Biological Activity

Wasp toxin analog. More potent than PhTX-343 at locust NMJ. Reported to be selective for NMDA receptors in mammalian CNS.