130235-82-4

Basic information

• Product Name: 2-(1-(4-methyl-2-phenylthiazole-5-yl)ethylidene)hydrazinecarbothioamide
• Synonyms: 2-(1-(4-methyl-2-phenylthiazole-5-yl)ethylidene)hydrazinecarbothioamide
• CAS NO: 130235-82-4
• Molecular Weight: 290.413
• Mol File: 130235-82-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(1-(4-methyl-2-phenylthiazole-5-yl)ethylidene)hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-(4-methyl-2-phenylthiazole-5-yl)ethylidene)hydrazinecarbothioamide(130235-82-4)
• EPA Substance Registry System: 2-(1-(4-methyl-2-phenylthiazole-5-yl)ethylidene)hydrazinecarbothioamide(130235-82-4)

Safety Data

• Hazardous Substances Data: 130235-82-4(Hazardous Substances Data)

Upstream product

• 2227-79-4 benzenecarbothioamide 
• 100-47-0 benzonitrile 
• 3043-28-5 3-bromopentane-2,4-dione 
• 7520-94-7 5-acetyl-4-methyl-2-phenylthiazole 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 1236182-30-1 C₃₁H₂₅N₇S₃ 
• 1236182-28-7 C₂₇H₂₂N₆S₂ 
• 130235-85-7 1-(1-(4-methyl-2-phenylthiazol-5-yl)ethylidene)-2-(4-phenylthiazol-2-yl)hydrazine 
• 1236182-29-8 C₂₂H₂₀N₆S₂ 
• 130235-86-8 N-[4-(4-Chloro-phenyl)-thiazol-2-yl]-N'-[1-(4-methyl-2-phenyl-thiazol-5-yl)-eth-(E)-ylidene]-hydrazine 
• 130235-87-9 N-[1-(4-Methyl-2-phenyl-thiazol-5-yl)-eth-(E)-ylidene]-N'-(4-thiophen-2-yl-thiazol-2-yl)-hydrazine 
• 130235-85-7 N-[1-(4-Methyl-2-phenyl-thiazol-5-yl)-eth-(E)-ylidene]-N'-(4-phenyl-thiazol-2-yl)-hydrazine 
• 130235-89-1 N-[4-(4-Methoxy-phenyl)-thiazol-2-yl]-N'-[1-(4-methyl-2-phenyl-thiazol-5-yl)-eth-(E)-ylidene]-hydrazine 
• 130235-88-0 N-[1-(4-Methyl-2-phenyl-thiazol-5-yl)-eth-(E)-ylidene]-N'-(4-p-tolyl-thiazol-2-yl)-hydrazine 

Relevant articles and documents

New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation

New bithiazolyl hydrazones (6a–l) have been first time synthesized by carrying novel one pot cyclocondensation of 5-acyl thiazoles (1a–b), thiosemicarbazide (2) and substituted phenacyl chlorides (4a–f) in freshly prepared ionic liquid, diisopropyl ethyl ammonium acetate (DIPEAc) at room temperature. The newly synthesized compounds have been evaluated for their antitubercular activity and the compounds 3b, 6a, 6b, 6d, 6e, 6f, 6g, and 6l have displayed noticeable antitubercular activity compared to Rifampicin with tolerable cytotoxicity. All these compounds were also screened for their antibacterial activity and found that, compounds 6j and 6k have exhibited a very good antibacterial activity. Molecular docking study has shown better harmony with the evaluation trend shown by these compounds under in vitro antitubercular screening.

Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives

The increase in antibiotic resistance due to multiple factors has warranted the need for search of new compounds which are active against multidrug resistant pathogens. In this context a small focused library of thiosemicarbazide derivatives of 2-arylthiazole-4-carbaldehyde, 4-methyl-2-arylthiazole-5-carbaldehyde and 1-(4-methyl-2-arylthiazol-5-yl) ethanone, (5a–l) has been synthesized. The title compounds were screened for inhibitory activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) and Mycobacterium bovis Bacille Calmette Guerin (ATCC 35743) strains. The synthesized compounds, 5a–l were further assayed for their cytotoxic activity against the two human cancer cell lines, HeLa and human colon carcinoma 116 cell lines and showed no significant cytotoxic activity against these two cell lines at the maximum concentration evaluated. Further, the synthesized compounds were found to have potential antibacterial activity against Gram-negative bacteria, Escherichia coli, Pseudomonas flurescence and Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis. Most of the synthesized compounds showed moderate activity against fungal strain Candida albicans. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimycobacterial agent.