130328-09-5Relevant articles and documents
Cyclization-Activated Prodrugs. Basic Esters of 5-Bromo-2'-deoxyuridine
Saari, Walfred S.,Schwering, John E.,Lyle, Paulette A.,Smith, Steven J.,Engelhardt, Edward L.
, p. 2590 - 2595 (2007/10/02)
Some 3'- and 5'-glycyl> esters of 5-bromo-2'-deoxyuridine were prepared and evaluated in vitro as progenitors of the parent alcohol.The sters proved to be relatively stable at low pH but released 5-bromo-2'-deoxyuridine cleanly at rates which were pH and structure dependent.These basic esters are examples of cyclization-activated prodrugs in which generation of active drug is not linked to enzymatic cleavage but rather results from an intramolecular cyclization-elimination reaction.