130332-80-8

Basic information

• Product Name: 1,3,7-trimethyl-8-(phenylthio)-1H-purine-2,6(3H,7H)-dione
• Synonyms: 1,3,7-trimethyl-8-(phenylthio)-1H-purine-2,6(3H,7H)-dione
• CAS NO: 130332-80-8
• Molecular Weight: 302.357
• Mol File: 130332-80-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,3,7-trimethyl-8-(phenylthio)-1H-purine-2,6(3H,7H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,7-trimethyl-8-(phenylthio)-1H-purine-2,6(3H,7H)-dione(130332-80-8)
• EPA Substance Registry System: 1,3,7-trimethyl-8-(phenylthio)-1H-purine-2,6(3H,7H)-dione(130332-80-8)

Safety Data

• Hazardous Substances Data: 130332-80-8(Hazardous Substances Data)

Upstream product

• 108-98-5 thiophenol 
• 58-08-2 3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione 
• 85-18-7 8-chlorotheophylline 
• 10381-82-5 8-bromocaffeine 
• 930-69-8 sodium thiophenolate 
• 4921-49-7 8-chlorocaffeine 
• 882-33-7 diphenyldisulfane 

Downstream Products

• 6439-88-9 1,3,7-trimethyl-8-phenylxanthine 
• 99765-13-6 (E)-8-(2-Phenylethenyl)-3,7-dihydro-1,3,7-trimethyl-1H-purin-2,6-dion 

Relevant articles and documents

Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent

A series of nine thio-caffeine analogues were synthesized and characterised by NMR, FT-IR and MS spectroscopic methods. Molecular structures of four of them were determined using single crystal X-ray diffraction methods. The antioxidant properties of all

8-R-thio- and 8-R-sulfonylcaffeine derivatives.

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MLKL INHIBITORS

Purine derivatives that inhibit cellular necroptosis and/or human MLKL, pharmaceutical compositions thereof, and methods of treating an MLKL-mediated disorder with an effective amount of the compound or composition. Said MLKL-mediated disorder is pathology associated necroptosis, including ischemia-reperfusion damage, neurodegeneration, and inflammatory diseases such as acute pancreatitis, multiple sclerosis, inflammatory bowel disease, and allergic colitis.