1303507-83-6

Basic information

• Product Name: N-benzyloxy-α-bromopropionamide
• Synonyms: N-benzyloxy-α-bromopropionamide
• CAS NO: 1303507-83-6
• Molecular Weight: 258.115
• Mol File: 1303507-83-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-benzyloxy-α-bromopropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyloxy-α-bromopropionamide(1303507-83-6)
• EPA Substance Registry System: N-benzyloxy-α-bromopropionamide(1303507-83-6)

Safety Data

• Hazardous Substances Data: 1303507-83-6(Hazardous Substances Data)

Upstream product

• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 563-76-8 α-bromopropionyl bromide 
• 622-33-3 N-benzyloxyamine 

Relevant articles and documents

Regio- and Diastereoselective Access to 4-Imidazolidinones via an Aza-Mannich Initiated Cyclization of Sulfamate-Derived Cyclic Imines with α-Halo Hydroxamates

An efficient regio- and diastereoselective cyclization of sulfamate-derived cyclic imines with unsubstituted or monosubstituted α-halo hydroxamates is developed under mild conditions. This reaction proceeds smoothly under transition-metal-free conditions via a domino aza-Mannich addition/intramolecular nucleophilic substitution sequence, providing a convenient route to access 2-monosubstituted and 2,5-disubstituted 4-imidazolidinones. Notably, the products were obtained with single trans-isomers in moderate to excellent yields.

Direct N- sec -Alkylation of Amides by Reaction of α-Halohydroxamates and Sulfonylindoles: An Approach to 3-Indolyl Methanamines

A catalyst-free, base-mediated N- sec -alkylation of amides by reaction of sulfonylindoles and α-halohydroxamates has been developed. The N- sec -alkylation of amides reaction is based on an intermolecular nucleophilic addition of vinylogous imine with N

Synthesis of spirobarbiturate-pyrrolidinones: Via a domino aza-Michael/SN2 cyclization of barbiturate-derived alkenes with N-alkoxy α-haloamides

A highly efficient domino aza-MIRC (Michael Induced Ring Closure) reaction between barbiturate-derived alkenes and N-alkoxy α-haloamides has been achieved in moderate to excellent yields. This reaction proceeds smoothly under mild conditions via a domino aza-Michael addition/intramolecular SN2 sequence, providing a practical tool in the synthesis of bioactive molecules spirobarbiturate-3-pyrrolidinones.