1303609-20-2Relevant articles and documents
Synthesis and Physicochemical Properties of 3-Fluorocyclobutylamines
Chernykh, Anton V.,Radchenko, Dmytro S.,Chernykh, Alla V.,Kondratov, Ivan S.,Tolmachova, Nataliya A.,Datsenko, Olexandr P.,Kurkunov, Maxim A.,Zozulya, Sergey X.,Kheylik, Yuri P.,Bartels, Katharina,Daniliuc, Constantin G.,Haufe, Günter
supporting information, p. 6466 - 6471 (2015/10/19)
Hitherto unknown cis- and trans-3-alkyl- and 3-aryl-3-fluorocycobutylamines have been synthesised selectively from 3-oxocyclobutane carboxylic acid in six or seven steps. Comparison of their pKa and logD values with those of the fluorine-free p
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
Zhao, Yujun,Liu, Liu,Sun, Wei,Lu, Jianfeng,McEachern, Donna,Li, Xiaoqin,Yu, Shanghai,Bernard, Denzil,Ochsenbein, Philippe,Ferey, Vincent,Carry, Jean-Christophe,Deschamps, Jeffrey R.,Sun, Duxin,Wang, Shaomeng
supporting information, p. 7223 - 7234 (2013/06/27)
Small-molecule inhibitors that block the MDM2-p53 protein-protein interaction (MDM2 inhibitors) are being intensely pursued as a new therapeutic strategy for cancer treatment. We previously published a series of spirooxindole-containing compounds as a new
