130380-48-2

Basic information

• Product Name: N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester
• CAS NO: 130380-48-2
• Molecular Weight: 476.657
• Mol File: 130380-48-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester(130380-48-2)
• EPA Substance Registry System: N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester(130380-48-2)

Safety Data

• Hazardous Substances Data: 130380-48-2(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 111-70-6 n-heptan1ol 
• 13139-16-7 N-tert-butyloxy-isoleucine 
• 130380-37-9 L-Phenylalanin-heptylester-hydro-p-toluolsulfonat 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 

Downstream Products

• 26055-05-0 N-[N-(tert-butoxycarbonyl)-L-leucyl]-L-phenylalanine 

Relevant articles and documents

Comparative lipase-catalyzed hydrolysis of ethylene glycol derived esters. The 2-methoxyethyl ester as a protective group in peptide and glycopeptide synthesis

Comparison of the lipase-catalyzed cleavage of polar esters derived from ethylene glycol proved 2-methoxyethyl (ME) esters most favorable protecting groups for the carboxylic function of peptides and glycopeptides. They combine high substrate acceptance and iligh yields of hydrolysis with favorable physicochemical properties and advantageous solubility. The application of this polar ester as protecting group was extended to N-glycosylated amino acids and N-glycopeptides. The selective removal of ME esters by lipases was achieved under mild conditions (pH 7.0 and 37°C), leaving all other linkages including peptide bonds and other ester protecting groups unaffected.