130383-75-4

Basic information

• Product Name: S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR
• Synonyms: S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR;(S)-(?)-3-Iodo-2-hydroxy-6-methoxy-N[(1-ethyl-2-pyrrolidinyl)methyl]benzamide
• CAS NO: 130383-75-4
• Molecular Formula: C15H21IN2O3
• Molecular Weight: 404.242
• Mol File: 130383-75-4.mol
• Article Data: 5

Chemical Properties

• Appearance: dark yellow/oil
• Storage Temp.: 2-8°C
• Solubility: H2O: <0.5 mg/mL, slightly soluble
• CAS DataBase Reference: S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR(CAS DataBase Reference)
• NIST Chemistry Reference: S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR(130383-75-4)
• EPA Substance Registry System: S(-)-IBZM (IODOBENZAMIDE) D2 DOPAMINE RE CEPTOR(130383-75-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 130383-75-4(Hazardous Substances Data)

Upstream product

• 96897-88-0 N-((S)-1-Ethyl-pyrrolidin-2-ylmethyl)-3-iodo-2,6-dimethoxy-benzamide 
• 22795-99-9 (S)-2-(Aminomethyl)-1-ethylpyrrolidine 
• 3147-64-6 2-hydroxy-6-methoxybenzoic acid 
• 1466-76-8 2-6-dimethoxybenzoic acid 
• 113452-76-9 3-iodo-6-methoxysalicylic acid 
• 90347-70-9 3-iodo-2,6-dimethoxybenzoic acid 
• 84226-04-0 (-)-BZM 
• 22795-97-7 (R)-2-aminomethyl-1-ethylpyrrolidine 

Relevant articles and documents

Silver(I)-catalyzed iodination of arenes: Tuning the lewis acidity of N-iodosuccinimide activation

A mild and rapid method for the iodination of arenes that utilizes silver(I) triflimide as a catalyst for activation of N-iodosuccinimide has been developed. The transformation was found to be general for a wide range of anisole, aniline, acetanilide, and phenol derivatives and allowed the late-stage iodination of biologically active compounds such as PIMBA, a SPECT imaging agent of breast cancer, and (a?)-IBZM, a dopamine D2 receptor antagonist. The method was also modified for the radioiodination of arenes using a one-pot procedure involving the in situ generation of [125I]-N-iodosuccinimide followed by the silver(I)-catalyzed iodination.

RADIOTRACER PRECURSOR AND METHOD FOR PREPARING THE SAME

A precursor SnBZM for a dopamine receptor radiotracer and a method for preparing the same are revealed. The precursor includes a tributyltin group (Bu3Sn) that is easy to be replaced. Thus a dopamine receptor radiotracer 123I-IBZM ca

Potential neuroleptic agents. 3. Chemistry and antidopaminergic properties of substituted 6-methoxysalicylamides

A series of substituted 6-methoxysalicylamides were synthesized from their corresponding 2,6-dimethoxybenzamides by demethylation of one methoxy group with boron tribromide. Substituted 6-methoxysalicylamides having a lipophilic aromatic substituent in the 3-position para with respect to the methoxy group, e.g. a bromo or an iodo atom or an ethyl or a propyl group, and having an (S)-N-(1-alkyl-2-pyrrolidinyl)methyl moiety as the side chain were found to be potent blockers of [3H]spiperone binding in vitro and potent inhibitors of the apomorphine syndrome in the rat. Similar to remoxipride but in contrast to haloperidol, some of the substituted salicylamides show a 10-20 fold separation between the dose that inhibits hyperactivity and that which inhibits stereotypy. It was concluded that, besides the requirement of a lipophilic substitutent in the position para to the methoxy group for antidopamine activity in vivo, the formation of a coplanar six-membered pseudoring involving the amide moiety and the methoxy group is a structural requirement for activity in vitro.