1304141-61-4

Basic information

• Product Name: (2R,3R)-(-)-2,7-dimethyl-3-(4-methylbenzyl)indoline
• Synonyms: (2R,3R)-(-)-2,7-dimethyl-3-(4-methylbenzyl)indoline
• CAS NO: 1304141-61-4
• Molecular Weight: 251.371
• Mol File: 1304141-61-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R,3R)-(-)-2,7-dimethyl-3-(4-methylbenzyl)indoline(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-(-)-2,7-dimethyl-3-(4-methylbenzyl)indoline(1304141-61-4)
• EPA Substance Registry System: (2R,3R)-(-)-2,7-dimethyl-3-(4-methylbenzyl)indoline(1304141-61-4)

Safety Data

• Hazardous Substances Data: 1304141-61-4(Hazardous Substances Data)

Upstream product

• 5621-13-6 2,7-dimethyl-1H-indole 
• 104-87-0 4-methyl-benzaldehyde 
• 1609325-66-7 2,7-dimethyl-3-(4-methylbenzyl)-1H-indole 
• 75159-10-3 N-(4-methylbenzylidene)-p-toluenesulfonamide 
• 1357175-06-4 N-((2,7-dimethyl-1H-indol-3-yl)(p-tolyl)methyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Method for synthesizing chiral indoline from 2, 3-disubstituted indole generated in situ through asymmetric hydrogenation of palladium

The invention discloses a method for synthesizing chiral indoline from 2, 3-disubstituted indole generated in situ through palladium-catalyzed asymmetric hydrogenation. The method comprises the following steps: by using a 1-5mol% palladium catalyst, adding 1-2.0 equev. of an acid, and carrying out asymmetric hydrogenation on the in-situ generated 2, 3-disubstituted indole compound to obtain the corresponding chiral indoline compound of which the enantiomeric excess can be up to 97% at most. The method is simple and convenient to operate, practical, easy to implement, high in yield, environmentally friendly, available in catalyst business and mild in reaction condition, and has potential practical application value.

Pd-Catalyzed asymmetric hydrogenation of 3-(toluenesulfonamidoalkyl)indoles

A series of 2-substituted 3-(toluenesulfonamidoalkyl)indoles was synthesized by application of (EtO)2POH or iodine as the catalyst, and was hydrogenated using chiral Pd catalyst, giving the 2,3-disubstituted indolines with up to 97% ee. The Royal Society of Chemistry 2012.