130478-69-2

Basic information

• Product Name: (E)-2-Methyl-but-2-enoic acid hydroxymethyl-((S)-1-phenyl-ethyl)-amide
• CAS NO: 130478-69-2
• Molecular Weight: 233.31
• Mol File: 130478-69-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-Methyl-but-2-enoic acid hydroxymethyl-((S)-1-phenyl-ethyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-Methyl-but-2-enoic acid hydroxymethyl-((S)-1-phenyl-ethyl)-amide(130478-69-2)
• EPA Substance Registry System: (E)-2-Methyl-but-2-enoic acid hydroxymethyl-((S)-1-phenyl-ethyl)-amide(130478-69-2)

Safety Data

• Hazardous Substances Data: 130478-69-2(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 130478-67-0 (E)-2-Methyl-but-2-enoic acid ((S)-1-phenyl-ethyl)-amide 

Downstream Products

• 37505-07-0 (S)-2-hydroxy-2-methylbutyric acid 
• 130478-73-8 (S)-5-Ethyl-5-methyl-3-((S)-1-phenyl-ethyl)-oxazolidin-4-one 
• 130478-71-6 (R)-5-Ethyl-5-methyl-3-((S)-1-phenyl-ethyl)-oxazolidin-4-one 

Relevant articles and documents

Functionalisation of Unsaturated Amides: Synthesis of Chiral α- or β-Hydroxy Acids

Mercury cyclisation of hemiamidals containing a stereogenic centre affords diastereoisomeric mixtures of tetrahydro-1,3-oxazin-4-ones or oxazolidin-4-ones, which are easily separated by silica gel chromatography and hydrolysed to give chiral α- and β-hydroxy acids.