130516-76-6

Basic information

• Product Name: 4,4,5,8-tetramethyl-1-oxaspiro[2.5]octane
• Synonyms: 1-oxaspiro[2.5]octane, 4,4,5,8-tetramethyl-; 4,4,5,8-Tetramethyl-1-oxaspiro[2.5]octane
• CAS NO: 130516-76-6
• Molecular Formula: C₁₁H₂₀O
• Molecular Weight: 168.2759
• Mol File: 130516-76-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 187.9°C at 760 mmHg
• Flash Point: 59.6°C
• Density: 0.92g/cm³
• Vapor Pressure: 0.85mmHg at 25°C
• Refractive Index: 1.47
• CAS DataBase Reference: 4,4,5,8-tetramethyl-1-oxaspiro[2.5]octane(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,5,8-tetramethyl-1-oxaspiro[2.5]octane(130516-76-6)
• EPA Substance Registry System: 4,4,5,8-tetramethyl-1-oxaspiro[2.5]octane(130516-76-6)

Safety Data

• Hazardous Substances Data: 130516-76-6(Hazardous Substances Data)

Upstream product

• 2181-44-4 trimethylsulfonium methylsulfate 
• 130693-79-7 (+)-(3S,6S)-2,2,3,6-tetramethyl-1-cyclohexanone 
• 2181-42-2 trimethylsulphonium iodide 

Downstream Products

• 153061-02-0 (+)-(1R,3S,6S)-2,2,3,6-tetramethylcyclohexane-1-methanol 
• 153061-03-1 (+)-(1S,3S,6S)-2,2,3,6-tetramethylcyclohexane-1-methanol 
• 153061-01-9 (-)-(1S,3S,6S)-2,2,3,6-tetramethylcyclohexane-1-carbaldehyde 

Relevant articles and documents

Preparation of Optically Active Flowery and Woody-Like Odorant Ketones via Corey-Chaykovsky Oxiranylation: Irones and Analogues

α-, β-, and γ-Irones and analogues have been prepared from optically active (+)-1, (+)-6a,b, and (+)-17, via a Corey-Chaykovsky oxiranylation (Me2S, Me2SO4, Me2SO, NaOH) followed by isomerisation (SnCl4 or MgBr2). (+)-Dihydrocyclocitral (19a), obtained from (-)-citronellal, and analogue (+)-19b, were condensed with various ketones to afford (+)-21a-f, and after hydrogenation (+)-22a-f.A mild oxidative degradation of aldehydes (+)-trans- and (-)-cis-8a,b to ketones (-)-16a,b, as well as olfactive evaluations, 13C-NMR assignments, and absolute configurations of the intermediate epoxides, aldehydes, and alcohols are presented.