130546-33-7

Basic information

• Product Name: tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate
• Synonyms: tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate;N-BOC-2-(tosyloxyMethyl)Morpholine
• CAS NO: 130546-33-7
• Molecular Formula: C₁₇H₂₅NO₆S
• Molecular Weight: 371.4485
• Mol File: 130546-33-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate(130546-33-7)
• EPA Substance Registry System: tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate(130546-33-7)

Safety Data

• Hazardous Substances Data: 130546-33-7(Hazardous Substances Data)

Usage

Description

Tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate is a chemical compound with the molecular formula C15H25NO6S. It is a derivative of morpholine and is commonly used as a reagent in organic synthesis. This white crystalline solid is stable under normal conditions and has a wide range of applications in the field of organic chemistry.

Uses

Used in Organic Synthesis:
Tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate is used as a reagent for the synthesis of various pharmaceuticals and biologically active molecules. Its unique structure allows it to act as a protecting group for amines, facilitating the synthesis of complex organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate is used as a precursor in the synthesis of various drugs. Its ability to protect amines during the synthesis process makes it a valuable component in the development of new medications.
Used in Research and Development:
Tert-Butyl 2-((tosyloxy)Methyl)Morpholine-4-carboxylate is also utilized in research and development settings, where it aids in the exploration of new chemical reactions and the synthesis of novel compounds with potential applications in various fields.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 135065-69-9 tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate 
• 135065-71-3 (R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 40987-24-4 R,S-2-hydroxymethyl-4-benzylmorpholine 

Downstream Products

• 167143-43-3 4-t-butoxycarbonyl-2-{2-[2-(3-methoxyphenyl)ethyl]phenoxymethyl}morpholine 
• 167142-74-7 4-t-butoxycarbonyl-2-[2-(4-phenylbutyl)phenoxymethyl]morpholine 
• 1093619-52-3 C₂₁H₃₂N₂O₅ 

Relevant articles and documents

4-Substituted quinazoline derivatives as novel EphA2 receptor tyrosine kinase inhibitors

Erythropoietin-producing hepatocellular receptor tyrosine kinase subtype A2 (EphA2) is an attractive therapeutic target for suppressing tumor progression. In our efforts to discover novel small molecules to inhibit EphA2, a class of compound based on 4-substituted quinazoline containing 7-(morpholin-2-ylmethoxy) group was identified as a novel hit by high throughput screening campaign. Structural modification of parent quinazoline scaffolds by introducing substituents on aniline displayed potent inhibitory activities toward EphA2.

PHARMACEUTICALLY ACTIVE PYRAZOLO-TRIAZINE AND/OR PYRAZOLO-PYRIMIDINE DERIVATIVES

The present invention relates to pyrazolo [1,5 -a] [1,3,5 ]triazine and pyrazolo[1,5-a] pyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferative diseases, inflammatory diseases, immunological diseases, cardiovascular diseases and infectious diseases. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the pyrazo lo [1,5-a][1,3,5 ]triazine and pyrazolo [1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof.

[2-ω-phenylalkyl)phenoxy]alkylamines: Synthesis and dual dopamine2 (D2) and 5-hydroxytryptamine2 (5-HT2) receptor antagonistic activities

A series of [2-(ω-phenylalkyl)phenoxy]alkylamines was synthesized and their 5-hydroxytryptamine2 (5-HT2) and/or dopamine2 (D2) receptor antagonistic activities were examined in vitro. [2-(4- Phenylbutyl)phenoxy]