130612-75-8

Basic information

• Product Name: (2,2,2-trifluoroethyl) (4-methoxyphenyl) sulfide
• Synonyms: (2,2,2-trifluoroethyl) (4-methoxyphenyl) sulfide
• CAS NO: 130612-75-8
• Molecular Weight: 222.231
• Mol File: 130612-75-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (2,2,2-trifluoroethyl) (4-methoxyphenyl) sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: (2,2,2-trifluoroethyl) (4-methoxyphenyl) sulfide(130612-75-8)
• EPA Substance Registry System: (2,2,2-trifluoroethyl) (4-methoxyphenyl) sulfide(130612-75-8)

Safety Data

• Hazardous Substances Data: 130612-75-8(Hazardous Substances Data)

Upstream product

• 696-63-9 4-Methoxybenzenethiol 
• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 306-83-2 1,1,1-trifluoro-2,2-dichloroethane 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 696-62-8 para-iodoanisole 
• 75-89-8 2,2,2-trifluoroethanol 
• 37780-82-8 4-methoxyphenyl allyl sulfide 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 
• 143827-63-8 cinnamyl(4-methoxyphenyl)sulfane 
• 14897-48-4 S-(2,2,2-trifluoroethyl) ethanethioate 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 100-66-3 methoxybenzene 
• 199381-84-5 2,2,2-trifluoroethyl t-butyl sulfoxide 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 134024-35-4 p-methoxyphenyl 1-methoxy-2,2,2-trifluoroethyl sulfide 
• 130612-78-1 p-Methoxyphenyl 1,2,2,2-tetrafluoroethyl sulfide 

Relevant articles and documents

Trifluoroethyl sulfenylation or sulfinylation with 2,2,2-trifluoroethyl t-butyl sulfoxide

Treatment of 2,2,2-trifluoroethyl-t-butyl sulfoxide 8 under acylating conditions, in the presence of various alkenes or 1-hexyne gives β-trifluoroacetoxy trifluoroethyl thioethers in good yields. Activated aromatic compounds furnish ortho and mainly para-

Hemin Catalyzed Dealkylative Intercepted [2, 3]-Sigmatropic Rearrangement Reactions of Sulfonium Ylides with 2, 2, 2-Trifluorodiazoethane

A dealkylative intercepted [2, 3]-sigmatropic rearrangement reaction of allylic sulfides with 2, 2, 2-trifluorodiazoethane (CF3CHN2) is reported, the commercially available and biocompatible catalyst hemin was found to efficiently catalyze this transformation across a diverse set of allylic sulfides with in situ generated CF3CHN2, providing excellent yields (up to 99%) under mild condition without inert gas protection. In addition, CF3CHN2 exhibited unique reactivity toward this process compared with other frequently used diazo reagents. This work expands the range of carbene-mediated transformations catalyzed by hemin and introduces a concise and general strategy for exploiting new possibility of reactions concerning organosulfides. (Figure presented.).

Copper-Catalyzed 2,2,2-Trifluoroethylthiolation of Aryl Halides

Herein, a copper-catalyzed 2,2,2-trifluoroethylthiolation reaction of aryl bromides and iodides with elemental sulfur, and 1,1,1-trifluoro-2-iodoethane is described. The reaction showed excellent functional group tolerance and allowed the synthesis of various substituted aryl 2,2,2-trifluoroethyl thioethers with good to excellent yields. This transformation constitutes a one-pot synthesis of 2,2,2-trifluoroethylthiolated compounds from inexpensive, readily available starting materials. Utility of the protocol was further demonstrated in the late-stage synthesis of the pirfenidone derivative. The copper thiolate species were prepared and proposed as key intermediates in the catalytic cycle.