130641-38-2 Usage
Description
Bindarit is an inhibitor of monocyte chemoattractant protein (MCP) production, selectively targeting MCP-1/CCL2, MPC-3/CCL7, and MCP-2/CCL8 over other chemokines. It possesses anti-inflammatory activity and acts as a protein antidenaturant agent, modulating the NFkB pathway. Bindarit has demonstrated potential in reducing the secondary phase of adjuvant arthritis in rats and exhibits a range of applications across different industries.
Uses
Used in Pharmaceutical Industry:
Bindarit is used as an anti-inflammatory agent for its selective inhibition of a subfamily of inflammatory chemokines, reducing inflammation and modulating the NFkB pathway.
Used in Autoimmune Disease Treatment:
Bindarit is used as a therapeutic agent for autoimmune diseases, such as lupus nephritis, by delaying the onset of proteinuria and prolonging survival in mouse models when administered at a specific dose.
Used in Neurological Disorder Treatment:
Bindarit is used as a treatment for neurological disorders, such as experimental autoimmune encephalomyelitis (EAE) in mice, by reducing the incidence and severity of the condition.
Used in Inflammation and Chemotactic Protein Inhibition:
Bindarit is used as a selective inhibitor against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, exhibiting its potential in modulating immune responses and inflammation.
Used in Drug Delivery and Transport Inhibition:
Bindarit is used as a noncompetitive inhibitor of monocarboxylate transporter 4 (MCT4), selectively targeting MCT4 over MCT1, which may have implications in drug delivery and transport mechanisms.
Check Digit Verification of cas no
The CAS Registry Mumber 130641-38-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,6,4 and 1 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 130641-38:
(8*1)+(7*3)+(6*0)+(5*6)+(4*4)+(3*1)+(2*3)+(1*8)=92
92 % 10 = 2
So 130641-38-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H20N2O3/c1-19(2,18(22)23)24-13-16-15-10-6-7-11-17(15)21(20-16)12-14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3,(H,22,23)
130641-38-2Relevant articles and documents
PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES
-
Paragraph 0067-0069, (2021/01/23)
The invention in this disclosure is related to the processes of making Bindarit or derivatives thereof. Specifically, the present invention provides, in part, new processes for making 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives. By way of non-limiting example, synthesis and purification processes of 2-((1-benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid are provided by the invention in this disclosure.
PROCESS FOR THE PREPARATION OF 1-BENZYL-3-HYDROXYMETHYL- 1H- INDAZOLE AND ITS DERIVATIVES AND REQUIRED MAGNESIUM INTERMEDIATES
-
, (2011/02/24)
The present invention relates to the process for the conversion of 1-benzyl-3-hydroxymethyl-1H-indazole according to formula (II), to the 1-benzyl-3-hydroxymethyl-1H-indazole according to formula (I).