130774-56-0

Basic information

• Product Name: p-Methylbenzyl Trifluoromethanesulfinate
• Synonyms: p-Methylbenzyl Trifluoromethanesulfinate
• CAS NO: 130774-56-0
• Molecular Weight: 238.23
• Mol File: 130774-56-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: p-Methylbenzyl Trifluoromethanesulfinate(CAS DataBase Reference)
• NIST Chemistry Reference: p-Methylbenzyl Trifluoromethanesulfinate(130774-56-0)
• EPA Substance Registry System: p-Methylbenzyl Trifluoromethanesulfinate(130774-56-0)

Safety Data

• Hazardous Substances Data: 130774-56-0(Hazardous Substances Data)

Upstream product

• 589-18-4 4-Methylbenzyl alcohol 
• 1025373-45-8 trifluoromethanesulfonic acid anhydride 
• 66727-99-9 p-Methylbenzyl Trifluoromethanesulfenate 

Downstream Products

• 130774-58-2 1-methyl-4-((trifluoromethylsulfonyl)methyl)benzene 
• 34642-42-7 trifluoromethanesulfinic acid 
• 54191-22-9 1-(ethoxymethyl)-4-methylbenzene 
• 3395-88-8 4-methylbenzyl methyl ether 

Relevant articles and documents

Synthesis of Difluoromethanesulfinate Esters by the Difluoromethanesulfinylation of Alcohols

Herein, we report the first synthesis of difluoromethanesulfinate esters via the direct difluoromethanesulfinylation of alcohols with HCF2SO2Na/Ph2P(O)Cl. Primary, secondary, and tertiary alcohols were converted to the corresponding difluoromethanesulfinate esters in good to excellent yields under mild conditions. The late-stage functionalization of complexed biologically active natural products was also demonstrated. The method was extended to the trifluoromethanesulfinylation of alcohols using CF3SO2Na in the presence of a catalytic amount of Me3SiCl to provide trifluoromethanesulfinate esters.