1307740-88-0Relevant articles and documents
Fused heterocyclic amido compounds as anti-hepatitis C virus agents
Aoyama, Hiroshi,Sugita, Kazuyuki,Nakamura, Masahiko,Aoyama, Atsushi,Salim, Mohammed T.A.,Okamoto, Mika,Baba, Masanori,Hashimoto, Yuichi
experimental part, p. 2675 - 2687 (2011/06/11)
We identified a fused heteroaromatic amido structure based on the phenanthridine skeleton as a superior scaffold for candidate drugs with potent anti-HCV activity. Among the compounds synthesized, a phenanthridine analogue with a 1,3-dioxolyl group (24) possessed the most potent anti-HCV activity (EC50 value: 50 nM), with acceptable cytotoxicity. The structural development and structure-activity relationships of these compounds are described.