13078-91-6

Basic information

• Product Name: 2-(Indolin-3-yl)ethanaMine
• Synonyms: 2-(Indolin-3-yl)ethanaMine;2,3-dihydro-1H-Indole-3-ethanaMine;2-(Indolin-3-yl)
• CAS NO: 13078-91-6
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.23156
• Mol File: 13078-91-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 280°C at 760 mmHg
• Flash Point: 142.8°C
• Appearance: /
• Density: 1.041g/cm³
• Vapor Pressure: 0.00388mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.04±0.10(Predicted)
• CAS DataBase Reference: 2-(Indolin-3-yl)ethanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Indolin-3-yl)ethanaMine(13078-91-6)
• EPA Substance Registry System: 2-(Indolin-3-yl)ethanaMine(13078-91-6)

Safety Data

• Hazardous Substances Data: 13078-91-6(Hazardous Substances Data)

Usage

General Description

2-(Indolin-3-yl)ethanamine, also known as 2-IEA, is a chemical compound with a molecular formula C10H11N. It is an organic compound that contains an indoline ring and an amine group, making it a derivative of the neurotransmitter serotonin. 2-IEA has been studied for its potential as a therapeutic agent for various conditions, including depression, anxiety, and drug addiction. It has also been investigated for its potential use as a dopaminergic agent and potential treatment for Parkinson's disease. Its pharmacological properties make it an interesting compound for further research and development in the field of neuroscience and drug discovery.

InChI:InChI=1/C10H14N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,8,12H,5-7,11H2

Upstream product

• 771-51-7 indole-3-acetonitrile 
• 61-54-1 tryptamine 
• 19260-03-8 1-(1H-indol-3-yl)-N,N,N-trimethylmethanaminium methyl sulfate 

Downstream Products

• 82575-82-4 N-2-(indol-3-yl)ethyl-indole-3-acetamide 
• 907969-24-8 tert-butyl N-(2-indolin-3-ylethyl)carbamate 
• 193551-50-7 (2-bromophenyl)-(9H-β-carbolin-1-yl)-methanone 
• 169129-62-8 Benzhydrylidene-{2-[1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethyl}-amine 
• 169129-63-9 2-[1-(Toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-ethylamine 
• 169129-61-7 Benzhydrylidene-[2-(2,3-dihydro-1H-indol-3-yl)-ethyl]-amine 

Relevant articles and documents

FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS

The present invention relates to compounds of formulae I and H, or pharmaceutically acceptable salts or esters thereof. Further aspects of the invention relate to pharmaceutical compositions and therapeutic uses of said compounds in the treatment of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, inappropriate cellular inflammatory responses, or neurodegenerative disorders, preferably tauopathies, even more preferably, Alzheimer's disease.

Nucleophilic substitution reaction of N-2-(1-hydroxyindol-3-yl)ethylindole-3-acetamide and -1-hydroxyindole-3-acetamide

Syntheses of N-2-(1-hydroxyindol-3-yl)ethyl-1-hydroxyindole-3-acetamide (3a) and -indole-3-acetamide (4a) are reported. They undergo nucleophilic substitution reaction at the 1-position upon reaction with indole in 85% formic acid to give new type compounds, N-2-[1-(indol-3-yl)indol-3-yl]ethylindole-3-acetamide (13), N-2-(indol-3-yl)ethyl-(14), and N-2-[1-(indol-3-yl)indol-3-yl]ethyl-1-(indol-3-yl)indole-3-acetamide (15).

Cardiac-Slowing Amidines Containing the 3-Thioindole Group. Potential Antianginal Agents

A series of 3-thioindolamidines (and 3-indolamidines) related to mixidine (1) was studied for cardiac-slowing properties, allowing the discovery of activity for prototype thioindole 2.Structure-activity relationships were explored, leading to many potent antitachycardic agents (6-9, 12, 13, 15-17, 20, 23, 24, 30, 34, 35, 45, and 47-49).Relative to 2, cardiac-slowing activity is enhanced by substitution of the indole nitrogen with small (C1-C3) saturated alkyl groups (6-9), unsaturated alkyl groups (12, 13, and 15-17), or a methoxyethyl group (20); replacement of the N-methyl group with alkyl (23) or phenyl groups (24); and extension of the ethylene bridge by two methylene units (34).Dethio (i.e., 3-indole) analogues of 2 with alkyl substitution on the indole nitrogen (47-49) have greater activity as well.Several potent compounds were also found to have minimal myocardial depression (6-9, 13, 45, and 47).Secondary pharmacological testing is reported for thioindoles 2, 6, 7, 9, and 28.