1307870-93-4Relevant articles and documents
Total synthesis of solamargine
Wei, Guohua,Wang, Jing,Du, Yuguo
, p. 2930 - 2933 (2011/06/26)
Solamargine, (25R)-3β-{O-α-l-rhamnopyranosyl-(1→2)-[O- α-l-rhamnopyranosyl-(1→4)]-β-d-glucopyranosyloxy} -22α-N-spirosol-5-ene, has been synthesized in 13 steps in a 10.5% overall yield starting from the naturally abundant diosgenin. Condensation of a partially protected glucopyranosyl donor with an oxaza-spiro moiety, which was formed in one-pot azido reduction, significantly improved the synthesis of desired molecule. The target compound exhibited good cytotoxic activities against tumor cells HeLa, A549, MCF-7, K562, HCT116, U87, and HepG2 with IC 50 ranging from 2.1 to 8.0 μM.