130798-65-1

Basic information

• Product Name: 4,4-[4,4-Biphenyldiylbis(sulfonylamino)]bis(5-hydroxy-2,7-naphthalenedisulfonic acid) BiPhdiNaphdiOH-4(SO3Na)
• CAS NO: 130798-65-1
• Molecular Formula: C₃₂H₂₄N₂O₁₈S₆
• Mol File: 130798-65-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4,4-[4,4-Biphenyldiylbis(sulfonylamino)]bis(5-hydroxy-2,7-naphthalenedisulfonic acid) BiPhdiNaphdiOH-4(SO3Na)(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-[4,4-Biphenyldiylbis(sulfonylamino)]bis(5-hydroxy-2,7-naphthalenedisulfonic acid) BiPhdiNaphdiOH-4(SO3Na)(130798-65-1)
• EPA Substance Registry System: 4,4-[4,4-Biphenyldiylbis(sulfonylamino)]bis(5-hydroxy-2,7-naphthalenedisulfonic acid) BiPhdiNaphdiOH-4(SO3Na)(130798-65-1)

Safety Data

• Hazardous Substances Data: 130798-65-1(Hazardous Substances Data)

Upstream product

• 3406-84-6 biphenyl-4,4'-disulfonyl chloride 
• 5460-09-3 1-amino-8-hydroxy-naphthalene-3,6-disulphonic acid monosodium salt 

Relevant articles and documents

Potential anti-AIDS agents. Synthesis and antiviral activity of naphthalenesulfonic acid derivatives against HIV-1 and HIV-2

Certain naphthalenesulfonic acid analogues have been synthesized and evaluated for their inhibitory effects on HIV-1- and HIV-2-induced cytopathogenicity, HIV-1 giant cell formation, and HIV-1 reverse transcriptase (RT) activity. A bis(naphthalenedisulfonic acid) derivative having a biphenyl spacer emerged as the most potent and selective inhibitor of virus-induced cytopathogenicity in MT-4 cells. The ED50 values for this compound were 7.6 and 36 μM for HIV-1 and HIV-2, respectively. No toxicity to the host cells was detected at 98 μM. This compound also inhibited giant cell formation and was superseded in potency by a bis(naphthalenedisulfonic acid) derivative having a flexible decamethylene spacer. In the cell-free RT assay, a long-chain amide derivative exhibited the most inhibition of RT. All the compounds that achieved complete inhibition of virus-induced cytopathogenicity at concentrations not toxic to host cells were derivatives of 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid. These analogues represent new leads for the development of anti-HIV agents.