1308272-87-8

Basic information

• Product Name: N-(4-methylphenyl)-1-phenyl-1H-tetrazol-5-amine
• Synonyms: N-(4-methylphenyl)-1-phenyl-1H-tetrazol-5-amine
• CAS NO: 1308272-87-8
• Molecular Weight: 251.291
• Mol File: 1308272-87-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-methylphenyl)-1-phenyl-1H-tetrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)-1-phenyl-1H-tetrazol-5-amine(1308272-87-8)
• EPA Substance Registry System: N-(4-methylphenyl)-1-phenyl-1H-tetrazol-5-amine(1308272-87-8)

Safety Data

• Hazardous Substances Data: 1308272-87-8(Hazardous Substances Data)

Upstream product

• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 622-37-7 Phenyl azide 
• 10532-64-6 N-(4-methylphenyl)cyanamide 
• 106-49-0 p-toluidine 
• 103-72-0 phenyl isothiocyanate 
• 1145-66-0 1-(4-methylphenyl)-3-phenylthiourea 
• 19244-07-6 N-phenyl-N'-(4-methylphenyl)carbodiimide 

Relevant articles and documents

One-pot three-component tandem reaction: Synthesis of aryl/alkyl cyanamides libraries and their further conversion into tetrazole derivatives

We have developed methodology for the synthesis of aryl/alkyl cyanamides from amines in one-pot four steps reaction using cheap, readily available and air stable copper source as catalyst under mild reaction conditions. We have also studied the application of cyanamides. In this connection, we could construct aryl tetrazolamine from cyanamides using click reaction.

Tandem regioselective synthesis of tetrazoles and related heterocycles using iodine

A one-pot, tandem process has been developed for the synthesis of a library of tetrazoles from aryl isothiocyanates. Condensation of aryl isothiocyanates with ammonia, and aryl amines (R-NH2) provided mono, 1,3-disubstituted symmetrical and unsymmetrical thioureas, which on desulfurization with molecular iodine (I2) led to formation of the corresponding heterocumulene (cyanamides or carbodiimides). The in situ generated heterocumulene on subsequent treatment with sodium azide at room temperature gave corresponding tetrazoles. The product regioselectivity for unsymmetrical 1,3-disubstituted thioureas was found to be correlated with the basicities (pKa's) of the parent amines attached to the thiourea. Aryl-sec-alkyl unsymmetrical thioureas gave thioamido guanidino products rather than the 5-aminotetrazoles produced by HgCl2 mediation of the reaction. Bis-thioureas derived from aryl isothiocyanates and hydrazine gave thiadiazoles exclusively.