13084-29-2

Basic information

• Product Name: 2-(4-chlorophenyl)-4,5-dihydro-1,3-thiazole
• Synonyms: 2-(4-Chlorophenyl)-4,5-dihydro-1,3-thiazole; thiazole, 2-(4-chlorophenyl)-4,5-dihydro-
• CAS NO: 13084-29-2
• Molecular Formula: C₉H₈ClNS
• Molecular Weight: 197.6845
• Mol File: 13084-29-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 308.9°C at 760 mmHg
• Flash Point: 140.6°C
• Density: 1.32g/cm³
• Vapor Pressure: 0.00121mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: 2-(4-chlorophenyl)-4,5-dihydro-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-4,5-dihydro-1,3-thiazole(13084-29-2)
• EPA Substance Registry System: 2-(4-chlorophenyl)-4,5-dihydro-1,3-thiazole(13084-29-2)

Safety Data

• Hazardous Substances Data: 13084-29-2(Hazardous Substances Data)

Usage

Chemical structure

Contains a thiazole ring and a chlorine-substituted phenyl group

Kinase activity

Potent and selective inhibitor of the epidermal growth factor receptor (EGFR)

Therapeutic potential

Being investigated for its potential effects in the treatment of various cancers, particularly non-small cell lung cancer

Preclinical and clinical results

Has shown promising results in inhibiting tumor growth

Targeted therapy

Being studied for its potential as a targeted therapy in cancer treatment

Further research

Its chemical structure and mechanism of action make it a promising candidate for further research and development in the field of oncology.

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Downstream Products

• 96159-99-8 2-(4-Chloro-phenyl)-3-methyl-4,5-dihydro-thiazol-3-ium; iodide 
• 27149-26-4 2-(4-chlorophenyl)thiazole 

Relevant articles and documents

Tribromomelamine: A novel and efficient catalyst for the synthesis 2-arylthiazolines under solvent-free conditions

A novel procedure for the synthesis of 2-arylthiazolines through one-pot condensation of of nitriles with 2-aminoethanethiol in the presence of tribromomelamine as catalyst under solvent-free conditions is described.

Cu(II) immobilized on Fe3O4@Agarose nanomagnetic catalyst functionalized with ethanolamine phosphate–salicylaldehyde schiff base: A magnetically reusable nanocatalyst for preparation of 2-substituted imidazolines, oxazolines, and thiazolines

Herein we synthesized Cu(II) immobilized on Fe 3 O 4 @Agarose functionalized with ethanolamine phosphate–salicylaldehyde Schiff base (Fe 3 O 4 @Agarose/SAEPH 2 /Cu(II)) as a new and cost-effective nanomagnetic catalyst. The nanomagnetic catalyst was characterized by FT- IR, XRD, VSM, SEM- EDX, TEM, TGA, and ICP techniques and it was found that the particles were about 9–25 nm in size and spherical with entrapment of the Fe 3 O 4 particles in the hollow pore structure of the agarose. The prepared nanomagnetic catalyst showed excellent activity for preparation of 2-substituted imidazolines, oxazolines, and thiazolines. The catalyst is easy to prepare and exhibits higher catalytic activity than some commercially available copper sources. More importantly, this nanomagnetic catalyst can be easily recovered by using a permanent magnet and reused for at least seven cycles without significant deactivation.

A straightforward metal-free synthesis of 2-substituted thiazolines in air

A base-catalysed procedure for the synthesis of 2-substituted thiazolines from nitriles and cysteamine hydrochloride under solvent-free conditions is presented. This straightforward approach allows high conversion for a broad range of nitriles and an easy