130860-11-6 Usage
Description
2'-O-(TERT-BUTYLDIMETHYLSILYL)-3'-O-(PHENOXYTHIONCARBONYL)-5'-O-TRITYLURIDINE is a white crystalline solid with potential applications in the fields of cancer and viral treatment. Its chemical structure provides a protective feature that enhances its stability and utility in these areas.
Uses
Used in Pharmaceutical Industry:
2'-O-(TERT-BUTYLDIMETHYLSILYL)-3'-O-(PHENOXYTHIONCARBONYL)-5'-O-TRITYLURIDINE is used as a potential anti-cancer agent for its ability to target and combat cancer cells. Its protective properties may contribute to its effectiveness in this application.
2'-O-(TERT-BUTYLDIMETHYLSILYL)-3'-O-(PHENOXYTHIONCARBONYL)-5'-O-TRITYLURIDINE is also used as a potential anti-viral agent, leveraging its protective features to inhibit viral replication and spread.
Check Digit Verification of cas no
The CAS Registry Mumber 130860-11-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,0,8,6 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 130860-11:
(8*1)+(7*3)+(6*0)+(5*8)+(4*6)+(3*0)+(2*1)+(1*1)=96
96 % 10 = 6
So 130860-11-6 is a valid CAS Registry Number.
InChI:InChI=1/C41H44N2O7SSi/c1-40(2,3)52(4,5)50-36-35(49-39(51)47-32-24-16-9-17-25-32)33(48-37(36)43-27-26-34(44)42-38(43)45)28-46-41(29-18-10-6-11-19-29,30-20-12-7-13-21-30)31-22-14-8-15-23-31/h6-27,33,35-37H,28H2,1-5H3,(H,42,44,45)/t33-,35+,36+,37-/m1/s1
130860-11-6Relevant articles and documents
Nucleosides. LVI. Synthesis and chemical modifications of 3'-deoxy- pyrimidine nucleosides
Rhie,Pfleiderer
, p. 1425 - 1452 (2007/10/02)
3'-Deoxyuridine(1) and 3'-deoxycytidine(2) were prepared with improved yields by two different methods applying either the Barton procedure to appropriate 2',5'-di-O-protected pyrimidine nucleosides or by choosing the direct glycosylation of the pyrimidine bases with 1,2-di-O-acetyl-5-O- toluoyl-3-deoxy-D-erythro-pentofuranose via the silylation approach. Suitable protecting groups for the sugar moiety have been found in the trityl, tert- butyldimethylsilyl and the thexyl groups which are inert in the radical deoxygenation process. The newly synthesised compounds were characterized by elemental analyses and UV and 1H-NMR spectra.