130870-89-2

Basic information

• Product Name: 1-methyl-2,5-diphenyl-3-acetylpyrrole
• Synonyms: 1-methyl-2,5-diphenyl-3-acetylpyrrole
• CAS NO: 130870-89-2
• Molecular Weight: 275.35
• Mol File: 130870-89-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-methyl-2,5-diphenyl-3-acetylpyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2,5-diphenyl-3-acetylpyrrole(130870-89-2)
• EPA Substance Registry System: 1-methyl-2,5-diphenyl-3-acetylpyrrole(130870-89-2)

Safety Data

• Hazardous Substances Data: 130870-89-2(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 932-62-7 3-acetyl-1-methyl-1H-pyrrole 
• 108-86-1 bromobenzene 
• 2042-37-7 o-cyanobromobenzene 
• 838-40-4 2,5-diphenyl-1H-pyrrole 
• 85814-61-5 1-(2,5-diphenyl-1H-pyrrol-3-yl)ethanone 
• 74-88-4 methyl iodide 

Downstream Products

• 130870-96-1 1-(4-Bromo-1-methyl-2,5-diphenyl-1H-pyrrol-3-yl)-ethanone 

Relevant articles and documents

Palladium-catalysed regioselective sequential C-5 and C-2 direct arylations of 3-acetylpyrroles with aryl bromides

The PdCl(C3H5)(dppb)/KOAc system was found to be effective for the direct regioselective C-5 arylation of 3-acetylpyrroles with ortho-substituted aryl bromides. This procedure has been found to be tolerant to a variety of functional groups at C-2 of the aryl bromide such as methyl, formyl, nitrile, nitro, hydroxymethyl, chloro, fluoro or trifluoromethyl. The sequential direct C-5 arylation followed by C-2 arylation of such 3-substituted pyrroles allows the synthesis of 2,5-diaryl-3-acetylpyrroles in high yields. Copyright