1308872-02-7

Basic information

• Product Name: N-[2-(AcetylaMino)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranosyl]-N2-FMoc-L-asparagine
• Synonyms: N-[2-(AcetylaMino)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranosyl]-N2-FMoc-L-asparagine
• CAS NO: 1308872-02-7
• Molecular Formula: C33H41N3O14
• Molecular Weight: 703.69034
• Product Categories: Intermediates & Fine Chemicals;Oligosaccharides;Pharmaceuticals;Oligosaccharides, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1308872-02-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[2-(AcetylaMino)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranosyl]-N2-FMoc-L-asparagine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(AcetylaMino)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranosyl]-N2-FMoc-L-asparagine(1308872-02-7)
• EPA Substance Registry System: N-[2-(AcetylaMino)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranosyl]-N2-FMoc-L-asparagine(1308872-02-7)

Safety Data

• Hazardous Substances Data: 1308872-02-7(Hazardous Substances Data)

Usage

Description

N-[2-(AcetylaMino)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranosyl]-N2-FMoc-L-asparagine, also known as Fmoc-Asn(Fucα1,6GlcNAc)-OH, is an Asn-linked disaccharide derivative. It is a substrate of mutant Endo-β-N-acetylglucosaminidase, an enzyme derived from Streptococcus pneumoniae. This complex molecule is characterized by its unique structure, which includes an N-acetylated amino group, a deoxy sugar, and a fucopyranosyl linkage to a glucopyranosyl group. The molecule is further modified with an FMoc (9-fluorenylmethoxycarbonyl) protecting group on the asparagine residue, which is commonly used in peptide synthesis to protect the amino group from unwanted reactions.

Uses

Used in Pharmaceutical Industry:
N-[2-(AcetylaMino)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranosyl]-N2-FMoc-L-asparagine is used as a substrate for the study and development of mutant Endo-β-N-acetylglucosaminidase enzymes. These enzymes are of interest due to their potential applications in the treatment of bacterial infections caused by Streptococcus pneumoniae. By understanding the interaction between this disaccharide derivative and the enzyme, researchers can develop more effective therapies against this pathogen.
Used in Research and Development:
In the field of glycobiology and biochemistry, N-[2-(AcetylaMino)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranosyl]-N2-FMoc-L-asparagine serves as an important tool for studying the structure and function of glycoproteins and their role in various biological processes. The molecule can be used to investigate the specificity and activity of glycosidases, as well as to explore the role of glycosylation in protein folding, stability, and function.
Used in Drug Design and Synthesis:
The unique structure of N-[2-(AcetylaMino)-2-deoxy-6-O-(α-L-fucopyranosyl)-β-D-glucopyranosyl]-N2-FMoc-L-asparagine makes it a valuable compound for the development of new drugs targeting glycosidases and other enzymes involved in glycoprotein processing. By incorporating this disaccharide derivative into drug candidates, researchers can potentially enhance the selectivity and efficacy of these therapeutic agents.