1309460-29-4

Basic information

• Product Name: Acid-PEG5-t-butyl ester
• Synonyms: Acid-PEG5-t-butyl ester;COOH-PEG5-OtBu
• CAS NO: 1309460-29-4
• Molecular Formula: C18H34O9
• Molecular Weight: 394.45716
• Mol File: 1309460-29-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 495.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.109±0.06 g/cm3(Predicted)
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: Acid-PEG5-t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acid-PEG5-t-butyl ester(1309460-29-4)
• EPA Substance Registry System: Acid-PEG5-t-butyl ester(1309460-29-4)

Safety Data

• Hazardous Substances Data: 1309460-29-4(Hazardous Substances Data)

Usage

Description

Acid-PEG5-t-butyl ester is a PEGylated compound featuring a t-butyl protected carboxyl group and a terminal carboxylic acid, which can be activated to form stable amide bonds with primary amines. The hydrophilic PEG spacer enhances solubility in aqueous environments, and the t-butyl group can be removed under acidic conditions.

Uses

Used in Pharmaceutical Industry:
Acid-PEG5-t-butyl ester is used as a PEGylation agent for improving the solubility, stability, and bioavailability of therapeutic proteins and peptides. The terminal carboxylic acid allows for covalent attachment to primary amine groups, while the hydrophilic PEG spacer reduces immunogenicity and proteolytic degradation.
Used in Drug Delivery Systems:
Acid-PEG5-t-butyl ester is used as a component in the design of drug delivery systems, such as nanoparticles or hydrogels, to enhance the encapsulation and controlled release of therapeutic agents. The t-butyl protected carboxyl group can be deprotected under acidic conditions, allowing for triggered release in response to specific environmental stimuli.
Used in Bioconjugation:
Acid-PEG5-t-butyl ester is used as a bioconjugation reagent for the site-specific attachment of biomolecules, such as antibodies or enzymes, to various surfaces or carriers. The terminal carboxylic acid enables selective coupling to primary amine groups, while the PEG spacer provides steric stabilization and reduces non-specific interactions.