1309593-62-1

Basic information

• Product Name: tert-butyl [4-(2-amino[1,2,4]triazolo[1,5-α]pyridin-6-yl)phenyl]carbamate
• Synonyms: tert-butyl [4-(2-amino[1,2,4]triazolo[1,5-α]pyridin-6-yl)phenyl]carbamate
• CAS NO: 1309593-62-1
• Molecular Weight: 325.37
• Mol File: 1309593-62-1.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: tert-butyl [4-(2-amino[1,2,4]triazolo[1,5-α]pyridin-6-yl)phenyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [4-(2-amino[1,2,4]triazolo[1,5-α]pyridin-6-yl)phenyl]carbamate(1309593-62-1)
• EPA Substance Registry System: tert-butyl [4-(2-amino[1,2,4]triazolo[1,5-α]pyridin-6-yl)phenyl]carbamate(1309593-62-1)

Safety Data

• Hazardous Substances Data: 1309593-62-1(Hazardous Substances Data)

Upstream product

• 1010120-60-1 ethyl [(5-bromopyridin-2-yl)carbamothioyl]carbamate 
• 947248-68-2 6-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine 
• 380430-49-9 [4-(tert-butoxycarbonylamino)phenyl]boronic acid 
• 1072-97-5 5-bromo-2-pyridylamine 

Downstream Products

• 1309593-65-4 tert-butyl (4-{2-[(2-methoxyphenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)carbamate 
• 1309593-63-2 tert-butyl (4-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)carbamate 
• 1309593-67-6 tert-butyl [4-(2-{[2-(trifluoromethyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]carbamate 
• 1309593-71-2 C₂₅H₂₄N₆O₂ 
• 1309593-64-3 2-{[6-(4-aminophenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}benzonitrile 
• 1309680-98-5 N-(4-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)acetamide 
• 1309593-66-5 6-(4-aminophenyl)-N-(2-methoxyphenyl)[1, 2,4]triazolo[1,5-a]pyridin-2-amine 
• 1309593-68-7 6-(4-aminophenyl)-N-[2-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine 
• 1309593-69-8 2-chloro-N-[4-(2-{[2-(trifluoromethyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide 
• 1309593-72-3 2-{[6-(4-aminophenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino}-4-methylbenzonitrile 
• 1309681-11-5 N-(4-{2-[(2-cyanophenyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)-3,3,3-trifluoropropanamide 
• 1309593-73-4 6-(4-aminophenyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine 
• 1309682-19-6 N-[4-(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-3,3,3-trifluoropropanamide 
• 1443764-16-6 tert-butyl {4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-(2,2,2-trifluoroethoxy)phenyl}amino)[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}carbamate 

Relevant articles and documents

METHOD FOR PREPARING SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to methods of preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as to intermediate compounds useful in the preparation of said compounds.

COMBINATIONS FOR THE TREATMENT OF CANCER

The present invention relates to combinations of at least two compounds A and B, compound A being an inhibitor of Mps-1 kinase, and compound B being an inhibitor of an anti-apoptotic protein of the Bcl-2 family. Another aspect of the present invention relates to the use of such combinations as described supra for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of cancer. Another aspect of the present invention relates to the use of an anti- apoptotic protein from the Bcl-2 family as a sensitizer of cells to Mps-1 inhibitors. Another aspect of the present invention relates to the use of the ratio of pro-apoptotic and anti-apoptotic proteins from the Bcl-2 family in a biological sample as a biomarker for a Mps-1 kinase inhibitor treatment.

PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, processes for their preparation, and their use for the treatment and/or prophylaxis of diseases.