130972-90-6

Basic information

• Product Name: Carbamic acid, [[4-(2-bromoethoxy)-3-methoxyphenyl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 130972-90-6
• Molecular Formula: C15H22BrNO4
• Molecular Weight: 360.248
• Mol File: 130972-90-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [[4-(2-bromoethoxy)-3-methoxyphenyl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [[4-(2-bromoethoxy)-3-methoxyphenyl]methyl]-, 1,1-dimethylethyl ester(130972-90-6)
• EPA Substance Registry System: Carbamic acid, [[4-(2-bromoethoxy)-3-methoxyphenyl]methyl]-, 1,1-dimethylethyl ester(130972-90-6)

Safety Data

• Hazardous Substances Data: 130972-90-6(Hazardous Substances Data)

Upstream product

• 1196-92-5 Vanillylamin 
• 24424-99-5 di-tert-butyl dicarbonate 
• 130972-89-3 (4-hydroxy-3-methoxybenzyl)carbamic acid tert-butyl ester 
• 7149-10-2 vanillylamine hydrochloride 
• 106-93-4 ethylene dibromide 

Downstream Products

• 130972-91-7 {4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-carbamic acid tert-butyl ester 
• 289903-50-0 tert-butyl N-[4-(2-azidoethoxy)-3-methoxybenzyl]carbamate 
• 289903-56-6 4-(2-azidoethoxy)-3-methoxybenzylisothiocyanate 
• 289903-58-8 2,2-Dimethyl Propionic Acid 2-{3-[4-(2-Azidoethoxy)-3-methoxybenzyl]thioureido Methyl}-3-(3,4-dimethylphenyl)propyl ester 
• 289903-60-2 2,2-Dimethyl Propionic Acid 2-{3-[4-(2-Azidoethoxy)-3-methoxybenzyl]thioureido Methyl}-3-(4-t-butylphenyl)propyl Ester 
• 139693-27-9 4-(2-phthalimidoethoxy)-3-methoxybenzylisothiocyanate 
• 184003-38-1 1-{4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethoxy]-3-methoxy-benzyl}-3-phenethyl-thiourea 

Relevant articles and documents

The SAR analysis of TRPV1 agonists with the α-methylated B-region

A series of TRPV1 agonists with amide, reverse amide, and thiourea groups in the B-region and their corresponding α-methylated analogues were investigated. Whereas the α-methylation of the amide B-region enhanced the binding affinities and potencies as agonists, that of the reverse amide and thiourea led to a reduction in receptor affinity. The analysis indicated that proper hydrogen bonding as well as steric effects in the B-region are critical for receptor binding.

Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics

In order to improve the analgesic activity and pharmacokinetics of thioureas 2 and 3, which we previously developed as potent vanilloid receptor (VR) agonists, we prepared and characterized phenolic modifications of them and of their amide surro-gates (7, 8). The aminoethyl analogue of the amide template 13 was a potent analgesic with an EC50 =0.96 μg/kg in the AA-induced writhing test and with better in vivo stability than the parent phenol. Copyright