1309943-60-9 Usage
Description
Methyl Methanethiosulfonate-13C, also known as MMTS-13C, is a stable isotope-labeled reagent derived from Methyl Methanethiosulfonate (MMTS). It is characterized by the presence of the carbon-13 isotope, which provides unique properties for specific applications in chemical and biological research. MMTS-13C is a pale yellow oil, indicating its lipophilic nature and potential for use in various chemical reactions and assays.
Uses
Used in Chemical and Biological Research:
Methyl Methanethiosulfonate-13C is used as a reagent for the rapid and selective modification of sulfhydryl groups of enzymes. This selective modification is crucial for studying the structure, function, and dynamics of proteins, particularly those involved in redox reactions and signal transduction pathways.
Used in Structural Biology:
In the field of structural biology, MMTS-13C is employed for mapping the pore-lining regions of the ryanodine receptor. The ryanodine receptor is a calcium-release channel that plays a critical role in cellular calcium signaling. By selectively modifying the sulfhydryl groups in these regions, researchers can gain insights into the receptor's structure and function, as well as its role in various physiological and pathological processes.
Used in Mass Spectrometry:
The incorporation of carbon-13 into MMTS-13C allows for its use in mass spectrometry-based proteomics. The isotopic labeling provides a means to differentiate between modified and unmodified peptides, enabling the identification and quantification of proteins and their post-translational modifications. This is particularly useful in studying protein-protein interactions, enzyme mechanisms, and the effects of drugs or other small molecules on protein function.
Used in Drug Discovery and Development:
Methyl Methanethiosulfonate-13C can be utilized in drug discovery and development processes, particularly in the identification of novel drug targets and the development of small molecule inhibitors or activators. The selective modification of sulfhydryl groups by MMTS-13C can help elucidate the binding sites and mechanisms of action of potential drug candidates, thereby facilitating the design of more effective and selective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 1309943-60-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,0,9,9,4 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1309943-60:
(9*1)+(8*3)+(7*0)+(6*9)+(5*9)+(4*4)+(3*3)+(2*6)+(1*0)=169
169 % 10 = 9
So 1309943-60-9 is a valid CAS Registry Number.
