131-56-6

Basic information

• Product Name: 2,4-Dihydroxybenzophenone
• Synonyms: (2,4-dihydroxyphenyl)phenyl-methanon;(2,4-Dihydroxyphenyl)-phenylmethanon (2,4-dihydroxybenzophenon);2,4-DHBP;2,4-Dihydroxtbenzophenone;2,4-Dihydroxybenzofenon;2,4-dihydroxy-benzophenon;2,4-dihydroxydiphenylketone;Advastab 48
• CAS NO: 131-56-6
• Molecular Formula: C₁₃H₁₀O₃
• Molecular Weight: 214.2167
• EINECS: 205-029-4
• Product Categories: Industrial/Fine Chemicals;Additives for Plastic;proteins
• Mol File: 131-56-6.mol
• Article Data: 43

Chemical Properties

• Melting Point: 144.5-147 °C(lit.)
• Boiling Point: 194 °C (1 mmHg)
• Flash Point: 125 °C
• Appearance: Yellow/Crystalline Powder
• Density: 1,32 g/cm3
• Vapor Pressure: 2.84E-07mmHg at 25°C
• Refractive Index: 1.5090 (estimate)
• Storage Temp.: -20°C
• Solubility: Chloroform (Slightly, Heated), Ethanol (Slightly, Heated)
• PKA: 7.72±0.35(Predicted)
• Water Solubility: insoluble
• Merck: 14,1106
• BRN: 1311566
• CAS DataBase Reference: 2,4-Dihydroxybenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dihydroxybenzophenone(131-56-6)
• EPA Substance Registry System: 2,4-Dihydroxybenzophenone(131-56-6)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36-36/37/38-61
• Safety Statements: 26-37/39-45-53
• WGK Germany: 2
• RTECS: DJ0700000
• TSCA: Yes
• Hazardous Substances Data: 131-56-6(Hazardous Substances Data)

Usage

Description

2,4-Dihydroxybenzophenone is a yellow crystalline powder that serves as a metabolite of Benzophenone, a compound utilized in the production of antihistamines, hypnotics, and insecticides. It is known for its chemical properties and versatile applications across various industries.

Uses

Used in Pharmaceutical Industry:
2,4-Dihydroxybenzophenone is used as a metabolite for the manufacturing of antihistamines, hypnotics, and insecticides, contributing to the development of essential medications for various health conditions.
Used in Paints and Plastics Industry:
As an ultraviolet light absorber, 2,4-Dihydroxybenzophenone is employed in the production of paints and plastics to enhance their durability and protect them from the harmful effects of UV radiation.
Used in Dye Industry:
2,4-Dihydroxybenzophenone is used as a coupling agent for the preparation of novel mordent and disperse azo dyes, which are synthesized by the coupling of various diazo solutions of aromatic amines with the compound.
Used in Polymer Industry:
The compound is utilized in the synthesis of ultraviolet absorbing monomers by reacting with glycidyl acrylate and glycidyl methacrylate. Additionally, it is used in the development of new polymerizable stabilizers, such as 4-benzoyl-2-(α-piperidino-2-chlorobenzyl)-3-hydroxyphenyl acrylate (BPBHA) and its corresponding methacrylate (BPBHMA), as well as 2-hydroxy-4-(3-methacryloxy-2-hydroxylpropoxy) benzophenone (BPMA), which is synthesized using 2,4-dihydroxybenzophenone (UV-0) and glycidyl methacrylate (GMA). These stabilizers play a crucial role in enhancing the stability and performance of polymers in various applications.

Preparation

Obtained by condensation of benzanilide with resorcinol in the presence of zinc chloride and phosphorous oxychloride at 130–140° for 1 h (25%).

Contact allergens

BZP-1 is used, for example, in paints, plastics, and nail varnishes.

Safety Profile

Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Recrystallise it from MeOH. [Beilstein 8 IV 2442.]

InChI:InChI=1/C13H10O3/c14-10-6-7-11(12(15)8-10)13(16)9-4-2-1-3-5-9/h1-8,14-15H

Synthetic route

Benzotrichlorid (98-07-7) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With ethanol; water at 60 - 80℃; for 9h; Temperature; Green chemistry;	99%
With water In ethanol at 40 - 50℃; for 4h; Temperature; Large scale;	97.6%
With ethanol und Eintragen des Reaktionsgemisches in heisses Wasser;

benzoic acid (65-85-0) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With phosphotungstic acid In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; for 5h; Catalytic behavior; Temperature; Friedel-Crafts Acylation;	99%
With aluminum oxide; methanesulfonic acid at 140℃; for 0.5h;	85%
With bismuth(lll) trifluoromethanesulfonate In neat (no solvent) at 180℃; for 0.5h; Friedel-Crafts Acylation; Microwave irradiation; chemoselective reaction;	85%

benzoyl chloride (98-88-4) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With aluminum (III) chloride In chlorobenzene at 90℃;	97.1%
With zinc at 50 - 52℃; for 0.0152778h; Friedel-Crafts acylation; microwave irradiation;	70%

benzoic acid anhydride (93-97-0) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With 5% CeO2 doped HZSM-5 zeolite In ethanol at 73℃; for 4h; Concentration; Reagent/catalyst; Green chemistry;	96.58%
With sulfuric acid at 130℃;

2,4-Dihydroxybenzaldehyde (95-01-2) + benzene (71-43-2) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
Stage #1: benzene With polymer-supported phenyliodine(III) diacetate; sulfuric acid In acetic acid at 20℃; for 60h; Substitution; Stage #2: 2,4-Dihydroxybenzaldehyde With sodium carbonate; lithium chloride; palladium dichloride In N,N-dimethyl-formamide at 60 - 70℃; for 4.5h; Substitution;	67%

diphenyliodonium bromide (1483-73-4) + 2,4-Dihydroxybenzaldehyde (95-01-2) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With sodium carbonate; lithium chloride; palladium dichloride In N,N-dimethyl-formamide at 60℃; for 4h; Arylation;	52%

2,4-diacetoxybenzophenone (75697-71-1) → 2,4-dihydroxybenzophenone (131-56-6) + 2-acetoxy-4-hydroxybenzophenone

Conditions	Yield
With Candida cylindracea lipase In di-isopropyl ether; butan-1-ol at 28 - 30℃; for 40h;	A 50% B 35%

benzoic acid phenyl ester (93-99-2) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With boron trifluoride diethyl etherate In benzene for 3h; crossover Friess rearrangement; Heating;	40%

recorcinol (108-46-3) + 3,6-dibenzoyloxy-1,2-pyridazine (848417-68-5) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With zinc(II) chloride at 120 - 130℃; for 7h;	35%

benzene-1,2-diol (120-80-9) + benzoic acid (65-85-0) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With zinc(II) chloride; trichlorophosphate at 65℃; for 3h;	30%

2,4-dimethoxybenzophenone (3555-84-8) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With aluminum tri-bromide; benzene

benzamide (55-21-0) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With zinc(II) chloride; trichlorophosphate at 130 - 140℃;

benzoyl chloride (98-88-4) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6) + resorcinol dibenzoate (94-01-9)

Conditions	Yield
With carbon disulfide; aluminium trichloride

benzonitrile (100-47-0) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With hydrogenchloride; diethyl ether; zinc(II) chloride und Kochen des entstandenen Ketimidhydrochlorids mit Wasser;
Darstellung durch Kondensation und nachfolgende Hydrolyse nach Hoesch;

N-phenyl-benzimidoyl chloride (4903-36-0) + recorcinol (108-46-3) → N-phenyl benzoyl amide (93-98-1) + 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
Verseifen des Reaktionsprodkts mit warmer verduennter Salzsaeure;

N-phenyl-benzimidoyl chloride (4903-36-0) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
at 100℃; und nachfolgendes Erwaermen mit verd.Salzsaeure;

N-phenyl benzoyl amide (93-98-1) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With zinc(II) chloride; trichlorophosphate at 130 - 140℃;

benzoic acid ethyl ester (93-89-0) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With zinc(II) chloride at 140℃;

2,4-diacetoxybenzophenone (75697-71-1) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With water; trifluoroacetic acid at 65℃; for 2h;	54 % Spectr.
With water; trifluoroacetic acid at 65℃; Rate constant;

benzamide (55-21-0) + (E)-3-Ureido-but-2-enoic acid ethyl ester (5435-44-9, 22243-66-9) + recorcinol (108-46-3) + trichlorophosphate (10025-87-3, 12599-09-6, 63736-95-8) → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
at 140℃;

resorcinolbenzein → 2,4-dihydroxybenzophenone (131-56-6) + 9-phenyl-9H-xanthene-3,6-diol (101937-13-7)

Conditions	Yield
With potassium hydroxide

6-hydroxy-9-phenyl-3H-xanthen-3-one (7282-86-2) + alcoholic potash → 2,4-dihydroxybenzophenone (131-56-6) + 3.6-dioxy-9-phenyl-xanthene

water (7732-18-5) + Benzotrichlorid (98-07-7) + recorcinol (108-46-3) → 2,4-dihydroxybenzophenone (131-56-6) + resorcinolbenzein

benzoic acid (65-85-0) + recorcinol (108-46-3) + ZnCl2 → 2,4-dihydroxybenzophenone (131-56-6) + resorcinolbenzein

Conditions	Yield
at 160℃;

1.3-dibenzoyloxy-benzene → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With aluminium trichloride at 180℃;

2.4-dioxy-benzophenon-anil → 2,4-dihydroxybenzophenone (131-56-6)

Conditions	Yield
With hydrogenchloride

UDP-glucose (133-89-1) + 2,4-dihydroxybenzophenone (131-56-6) → C19H20O8

Conditions	Yield
With C-glycosyltransferase from Mangifera indica In methanol at 40℃; for 12h; pH=6.6; Enzymatic reaction;	100%

2,4-dihydroxybenzophenone (131-56-6) + allyl bromide (106-95-6) → 2-hydroxy-4-prop-2-enyloxybenzophenone (2549-87-3)

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 60℃; for 6h;	98%
With potassium carbonate; potassium iodide In acetone for 4h; Heating;

2,4-dihydroxybenzophenone (131-56-6) + 3-(tosyloxy)benzyl alcohol (1425968-55-3) → 2,4-bis[3'-(tosyloxy)benzyloxy]benzophenone

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 24h;	98%

3-(1H-imidazol-1-yl)propan-1-amine (5036-48-6) + 2,4-dihydroxybenzophenone (131-56-6) → C19H19N3O2 (1334482-81-3)

Conditions	Yield
In toluene for 17.5h; Inert atmosphere; Reflux;	97.7%

formaldehyd (50-00-0) + 2,4-dihydroxybenzophenone (131-56-6) + chitosan hydrochloride SC12181, DDA 80%, Mw 9 kDa, Mn 2 kDa → N-((2,6-dihydroxy-3-benzoyl)phenyl)methylated chitosan DS 0.4

Conditions	Yield
Stage #1: formaldehyd; chitosan hydrochloride SC12181, DDA 80%, Mw 9 kDa, Mn 2 kDa In water at 65℃; for 1h; Stage #2: 2.4-dihydroxybenzophenone In methanol; water at 65℃; for 24h;	96%

2,4-dihydroxybenzophenone (131-56-6) + nickel(II) acetate tetrahydrate (6018-89-9) + Trimethylenediamine (109-76-2) → N,N'-bis-(4-(hydroxybenzophenylidene))-1,3-propylenediaminenickel(II)

Conditions	Yield
Stage #1: 2.4-dihydroxybenzophenone; Trimethylenediamine In methanol for 24h; Reflux; Stage #2: nickel(II) acetate tetrahydrate In methanol for 48h; Reflux;	96%

2,4-dihydroxybenzophenone (131-56-6) + ethylenediamine (107-15-3) → C15H16N2O2

Conditions	Yield
In methanol for 16h; Reflux;	96%

2,4-dihydroxybenzophenone (131-56-6) + 1-Chlorooctane (111-85-3) → Cyasorb UV531 (1843-05-6)

Conditions	Yield
With sodium carbonate; potassium carbonate at 98 - 120℃; Temperature;	95.3%
With sodium carbonate In N,N-dimethyl-formamide at 70℃; for 8h; Temperature; Reagent/catalyst; Solvent;	95%

2,4-dihydroxybenzophenone (131-56-6) + methyl chloroformate (79-22-1) → Carbonic acid 4-benzoyl-3-methoxycarbonyloxy-phenyl ester methyl ester

Conditions	Yield
With triethylamine In tetrahydrofuran 0 deg C to room temp., 0.5 to 1 h;	95%

2,4-dihydroxybenzophenone (131-56-6) + 11-bromoundecanoic acid ethyl ester (6271-23-4) → ethyl 11-(4-benzoyl-3-hydroxyphenoxy)undecanoate (36414-96-7)

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 48h;	95%

2,4-dihydroxybenzophenone (131-56-6) + tert-butylisonitrile (119072-55-8, 7188-38-7) + Di-tert-butyl acetylenedicarboxylate (66086-33-7) → di-tert-butyl 6-benzoyl-2-(tert-butylamino)-5-hydroxy-4H-chromene-3,4-dicarboxylate (1222096-61-8)

Conditions	Yield
In dichloromethane at 20℃; for 24.1667h; regioselective reaction;	95%

formaldehyd (50-00-0) + 2,4-dihydroxybenzophenone (131-56-6) + chitosan hydrochloride SC12181, DDA 80%, Mw 9 kDa, Mn 2 kDa → N-((2,6-dihydroxy-3-benzoyl)phenyl)methylated chitosan DS 0.1

Conditions	Yield
Stage #1: formaldehyd; chitosan hydrochloride SC12181, DDA 80%, Mw 9 kDa, Mn 2 kDa In water at 65℃; for 1h; Stage #2: 2.4-dihydroxybenzophenone In methanol; water at 65℃; for 24h;	95%

2,4-dihydroxybenzophenone (131-56-6) + carbonic acid dimethyl ester (616-38-6) → Benzophenone-3 (131-57-7)

Conditions	Yield
With sodium carbonate at 160 - 170℃; for 10h;	94%
With tetrabutylammomium bromide; sodium carbonate In methanol at 170 - 175℃; under 22502.3 - 30003 Torr; Temperature; Reagent/catalyst; Pressure; Large scale;	86.1%

2,4-dihydroxybenzophenone (131-56-6) + nickel(II) acetate tetrahydrate (6018-89-9) + 1,3-Diamino-2-hydroxypropane (616-29-5) → N,N'-bis-(4-(hydroxybenzophenylidene))-2-hydroxy-1,3-propylenediaminenickel(II)

Conditions	Yield
Stage #1: 2.4-dihydroxybenzophenone; 1,3-Diamino-2-hydroxypropane In methanol for 12h; Reflux; Stage #2: nickel(II) acetate tetrahydrate In methanol for 12h; Reflux;	94%

2,4-dihydroxybenzophenone (131-56-6) + nickel(II) acetate tetrahydrate (6018-89-9) + 1,2-diaminopropan (78-90-0, 10424-38-1) → N,N'-bis-(4-(hydroxybenzophenylidene))-1,2-propylenediaminenickel(II)

Conditions	Yield
Stage #1: 2.4-dihydroxybenzophenone; 1,2-diaminopropan In methanol for 18h; Reflux; Stage #2: nickel(II) acetate tetrahydrate In methanol for 12h; Reflux;	94%

2,4-dihydroxybenzophenone (131-56-6) + Cyclohexyl isocyanide (931-53-3) + Di-tert-butyl acetylenedicarboxylate (66086-33-7) → di-tert-butyl 6-benzoyl-2-(cyclohexylamino)-5-hydroxy-4H-chromene-3,4-dicarboxylate (1222096-56-1)

Conditions	Yield
In dichloromethane at 20℃; for 24.1667h; regioselective reaction;	93%

2,4-dihydroxybenzophenone (131-56-6) + Trimethylenediamine (109-76-2) → C29H26N2O4*0.5C3H10N2

Conditions	Yield
In methanol at 65 - 75℃; for 2h;	91.6%

formaldehyd (50-00-0) + 2,4-dihydroxybenzophenone (131-56-6) + dimethyl amine (124-40-3) → 3-(dimethylaminomethyl)-2,4-dihydroxybenzophenone

Conditions	Yield
With hydrogenchloride In methanol; water at 25℃; for 24h; Mannich reaction;	91%

2,4-dihydroxybenzophenone (131-56-6) + methylene chloride (74-87-3) → Benzophenone-3 (131-57-7)

Conditions	Yield
With tetrabutyl-ammonium chloride; sodium carbonate In tert-butyl methyl ether; water; chlorobenzene at 100℃; under 2250.23 Torr; for 2h; Temperature; Solvent; Reagent/catalyst; Pressure; Autoclave;	91%

4,4'-azobis(4-cyanopentanoic acid chloride) + 2,4-dihydroxybenzophenone (131-56-6) → Di-(3-hydroxy-4-benzoylphenyl)trans-4,4'-azobis(4-cyanovalerate)

Conditions	Yield
With pyridine In dichloromethane	90.5%

2,4-dihydroxybenzophenone (131-56-6) + (2,4-dinitro-phenyl)-hydrazine (119-26-6) → 2,4-dihydroxybenzophenone 2,4-dinitrophenylhydrazone

Conditions	Yield
With sulfuric acid In methanol at 50℃; for 0.5h;	90%
With hydrogenchloride In tetrahydrofuran; ethanol

2,4-dihydroxybenzophenone (131-56-6) + vinyl propionate (105-38-4) → 4-hydroxy-2-vinyloxyphenyl phenyl ketone + 2-hydroxy-4-vinyloxyphenyl phenyl ketone

Conditions	Yield
With sodium carbonate; chloro(1,5-cyclooctadiene)iridium(I) dimer In toluene at 100℃; for 3h;	A 2% B 90%

2,4-dihydroxybenzophenone (131-56-6) + Cyclohexyl isocyanide (931-53-3) + acetylenedicarboxylic acid diethyl ester (762-21-0) → diethyl 6-benzoyl-2-(cyclohexylamino)-5-hydroxy-4H-chromene-3,4-dicarboxylate (1222096-55-0)

Conditions	Yield
In dichloromethane at 20℃; for 24.1667h; regioselective reaction;	90%

2,4-dihydroxybenzophenone (131-56-6) + 2,3-dimethyl-7-[(3-methylbut-2-en-1-yl)oxy]-4-oxo-4H-chromene-8-carbaldehyde (1235254-10-0) → (1R,14R)-20-benzoyl-21-hydroxy-5,6,15,15-tetramethyl-4,12,16-trioxapentacyclo[12.8.0.02,11.03,8.017,22]docosa-2(11),3(8),5,9,17,19,21-heptaen-7-one

Conditions	Yield
With ethylenediamine diacetic acid; triethylamine In acetonitrile at 80 - 85℃; for 12h; Diels-Alder Cycloaddition; stereoselective reaction;	90%

2,4-dihydroxybenzophenone (131-56-6) + 1-(2,5-dimethylfuran-3-yl)-3-(2-hydroxyphenyl)prop-2-en-1-one → (6-(2,5-dimethylfuran-3-yl)-1-hydroxy-12H-6,12-methanodibenzo[d,g][1,3]dioxocin-2-yl)(phenyl)methanone

Conditions	Yield
With ethylenediamine diacetic acid In toluene at 20℃; for 8h; Michael Addition; Inert atmosphere; Reflux; regioselective reaction;	89%

Upstream product

• 3555-84-8 2,4-dimethoxybenzophenone 
• 101894-07-9 (2,4-Dihydroxy-phenyl)-diphenyl-methanol 
• 55-21-0 benzamide 
• 108-46-3 recorcinol 
• 98-88-4 benzoyl chloride 
• 4903-36-0 N-phenyl-benzimidoyl chloride 
• 100-47-0 benzonitrile 
• 98-07-7 Benzotrichlorid 
• 93-97-0 benzoic acid anhydride 
• 65-85-0 benzoic acid 
• 93-98-1 N-phenyl benzoyl amide 
• 93-89-0 benzoic acid ethyl ester 
• 75697-71-1 2,4-diacetoxybenzophenone 
• 93-99-2 benzoic acid phenyl ester 

Downstream Products

• 101293-72-5 5-dimethylaminomethyl-2,4-dihydroxy-benzophenone; hydrochloride 
• 102178-02-9 2,4-dihydroxy-5-piperidinomethyl-benzophenone; hydrochloride 
• 101894-07-9 (2,4-Dihydroxy-phenyl)-diphenyl-methanol 
• 3286-96-2 3,5-Dibrom-2,4-dihydroxy-benzophenon 
• 17200-19-0 4,6,4'',6''-tetrahydroxy-3,3''-sulfanediyl-di-benzophenone 
• 54162-64-0 2,4,2'',4''-tetrahydroxy-3,3''-sulfanediyl-di-benzophenone 
• 2284-30-2 4-benzylresorcinol 
• 3286-97-3 5-bromo-2,4-dihydroxy-benzophenone 
• 40990-79-2 2',4'-dihydroxy-5'-nitrobenzophenone 
• 1508-89-0 7-acetoxy-3,4-diphenyl-chromen-2-one 
• 16299-27-7 2-oxo-4-phenyl-2H-chromen-7-yl acetate 
• 75697-71-1 2,4-diacetoxybenzophenone 
• 14814-66-5 3-acetyl-2,4-dihydroxy-benzophenone 
• 16832-72-7 3,5-diacetyl-2,4-dihydroxy-benzophenone 

Related news

An environmentally friendly synthesis of 2,4-Dihydroxybenzophenone (cas 131-56-6) by the single-step O-mono-benzoylation of 1,3-dihydroxybenzene (resorcinol) and Fries rearrangement of intermediate resorcinol monobenzoate: the activity of acid-treated montmorillonite clay catalysts09/30/2019

Acid-treated montmorillonites belonging to the K series (supplied by Süd-Chemie) were tested as heterogeneous catalysts for the liquid-phase acylation of 1,3-dihydroxybenzene with benzoic acid; this reaction may represent an environmentally friendly alternative to the use of benzyltrichloride a...detailed

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The invention discloses a clean production method of 2,4-dihydroxy benzophenone, wherein the method comprises the steps: by using trichlorotoluene and resorcinol as initial raw materials, reacting ina water/ethanol system to generate 2,4-dihydroxy benzophenone, and concentrating, alkalizing, decolorizing and acidifying a mother solution to implement zero discharge of wastewater. According to themethod, cheap and easily available trichlorotoluene and resorcinol are used as starting materials, the production method is simple in process, green and environment-friendly, the product yield and purity are relatively high, and the method has a wide industrial application prospect.