1310065-00-9Relevant articles and documents
Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors
Chahrour, Osama,Abdalla, Ashraf,Lam, Frankie,Midgley, Carol,Wang, Shudong
, p. 3066 - 3069 (2011/06/24)
We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.