1310373-42-2

Basic information

• Product Name: (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3,5-dichloropicolinamide
• Synonyms: (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3,5-dichloropicolinamide
• CAS NO: 1310373-42-2
• Molecular Weight: 397.236
• Mol File: 1310373-42-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3,5-dichloropicolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3,5-dichloropicolinamide(1310373-42-2)
• EPA Substance Registry System: (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3,5-dichloropicolinamide(1310373-42-2)

Safety Data

• Hazardous Substances Data: 1310373-42-2(Hazardous Substances Data)

Upstream product

• 1432511-52-8 (S)-ethyl 3-((R)-1,1-dimethylethylsulfinamido)-3-(2-fluoro-5-nitrophenyl)butanoate 
• 81719-53-1 3,5-dichloropyridine-2-carboxylic acid 
• 1301740-78-2 (S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 1346145-61-6 (R)-2-methyl-propane-2-sulfinic acid [(S)-1-(2-fluoro-5-nitro-phenyl)-3-hydroxy-1-methyl-propyl]-amide 
• 1310374-19-6 [(S)-4-(5-amino-2-fluoro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl ester 
• 1310374-16-3 [(S)-4-(2-fluoro-5-nitro-phenyl)-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-yl]-carbamic acid tert-butyl ester 
• 1301740-77-1 (S)-4-(2-fluoro-5-nitrophenyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 1075230-62-4 (R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide 
• 1213413-42-3 (S)-3-amino-3-(2-fluoro-5-nitro-phenyl)-butyric acid methyl ester 
• 1254199-42-2 methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate 
• 1075230-65-7 (S)-3-amino-3-(2-fluoro-5-nitrophenyl)butan-1-ol 
• 79110-05-7 1-(2-fluoro-5-nitrophenyl)ethanone 

Relevant articles and documents

BACE1 inhibitors: A head group scan on a series of amides

A series of amides bearing a variety of amidine head groups was investigated as BACE1 inhibitors with respect to inhibitory activity in a BACE1 enzyme as well as a cell-based assay. Determination of their basicity as well as their properties as substrates

AMINO OXAZINE DERIVATIVES

This invention relates to 5,6-dihydro-4H-[1,3]oxazin-2-ylamine compounds of the formula wherein R1 to R5 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are BACE2 inhibitors and can be used as medicaments for the treatment or prevention of diseases such as diabetes.