131043-40-8 Usage
Classification
Nucleoside analog reverse transcriptase inhibitor
Medical Use
Treatment of HIV/AIDS
Mechanism of Action
Inhibits the activity of reverse transcriptase enzyme, crucial for HIV virus replication
Administration
Usually administered orally
Forms Available
Tablets, oral solutions
Combination Therapy
Typically used in combination with other antiretroviral medications
Efficacy
Reduces viral load and improves immune system function in HIV patients
Tolerance
Generally well-tolerated
Adverse Reactions
Can cause serious hypersensitivity reactions in some individuals
Check Digit Verification of cas no
The CAS Registry Mumber 131043-40-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,0,4 and 3 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 131043-40:
(8*1)+(7*3)+(6*1)+(5*0)+(4*4)+(3*3)+(2*4)+(1*0)=68
68 % 10 = 8
So 131043-40-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H14FN5O3/c12-7-4(2-18)6(19)1-5(7)17-3-14-8-9(17)15-11(13)16-10(8)20/h3-7,18-19H,1-2H2,(H3,13,15,16,20)/t4-,5?,6+,7-/m0/s1
131043-40-8Relevant articles and documents
Synthesis and antiviral activity of 2′-deoxy-6′-substituted carbocyclic nucleosides
Xue, Haitao,Guo, Shuang,Hu, Tianwen,Wei, Daibao,Xie, Yuanchao,Shen, Jingshan
, p. 561 - 572 (2021/12/23)
A series of 2′-deoxy carbocyclic nucleosides characterized by various 6′-substitutions were synthesized and evaluated for their antiviral activities against three viruses, including hepatitis B virus (HBV), hepatitis C virus, and influenza virus. The in vitro antiviral assays indicated that these nucleosides only showed inhibitory activities against HBV, and the substituted groups at the 6′ position significantly affected the activity. Among them, the guanosine analog 2b bearing a 6′-α-hydroxyl methyl group was the most potent compound with an EC50 value of 80?nM. The present study provided useful information for the discovery of antiviral carbocyclic nucleosides.