1310693-19-6Relevant articles and documents
Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control
Semple, Graeme,Ren, Albert,Fioravanti, Beatriz,Pereira, Guillherme,Calderon, Imelda,Choi, Karoline,Xiong, Yifeng,Shin, Young-Jun,Gharbaoui, Tawfik,Sage, Carleton R.,Morgan, Michael,Xing, Charles,Chu, Zhi-Liang,Leonard, James N.,Grottick, Andrew J.,Al-Shamma, Hussein,Liang, Yin,Demarest, Keith T.,Jones, Robert M.
, p. 3134 - 3141 (2011/06/26)
We herein outline the design of a new series of agonists of the pancreatic and GI-expressed orphan G-protein coupled receptor GPR119, a target that has been of significant recent interest in the field of metabolism, starting from our prototypical agonist
