1311276-83-1

Basic information

• Product Name: C₃₅H₃₇N₅O₆S
• CAS NO: 1311276-83-1
• Molecular Weight: 655.775
• Mol File: 1311276-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₅H₃₇N₅O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₅H₃₇N₅O₆S(1311276-83-1)
• EPA Substance Registry System: C₃₅H₃₇N₅O₆S(1311276-83-1)

Safety Data

• Hazardous Substances Data: 1311276-83-1(Hazardous Substances Data)

Upstream product

• 15761-50-9 2-amino-4-methylpentane 
• 943246-48-8 4-(7-fluoro-6-nitro-4-oxo-4H-chromen-2-yl)benzoic acid 
• 51333-80-3 1-isothiocyanato-3-methylsulfanylbenzene 
• 104091-09-0 (S)-2-[{({9H-fluoren-9-yl}methoxy)carbonyl}amino]pentanedioic acid 

Relevant articles and documents

Novel flavonoids with antiproliferative activities against breast cancer cells

A series of flavone analogues were synthesized and evaluated for their antiproliferation activity against breast cancer cells. The IC50 of compound 10 and 24 were determined to be at 5 μM. These compounds were used as baits to screen breast cancer cDNA expression phage display proteome library. DNA sequencing of the binding phages suggests that eEF1A1 is a target protein for 10 and 24. Further optimization of these compounds led to the discovery of 39 with higher cytotoxic potency (IC50 = 1 μM) and binding to eEF1A2. Biological and biochemical data suggest that eEF1A2 might be a therapeutic target and that 39 is an excellent lead compound for further development.