131184-65-1Relevant articles and documents
THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS
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Page/Page column 154, (2010/09/18)
The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer
Carbamoylimidazolium salts as diversification reagents: An application to the synthesis of tertiary amides from carboxylic acids
Grzyb, Justyna A.,Batey, Robert A.
, p. 7485 - 7488 (2007/10/03)
An efficient method for the preparation of tertiary amides from carbamoylimidazolium salts and carboxylic acids is described. The transformation occurs at room temperature and under relatively mild conditions. The carbamoylimidazolium salts are obtained from the reaction of secondary amines with N,N′-carbonyldiimidazole, followed by methylation with methyl iodide. The utility of this reaction was demonstrated in the formation of Weinreb amides and in a short synthesis of fused bicyclic amides. The introduction of this reaction now permits carbamoylimidazolium salts to be utilized in the formation of tertiary amides, ureas, carbamates and thiocarbamates under a single set of conditions.