13121-99-8

Basic information

• Product Name: PYRIDIN-4-YL-ACETONITRILE
• Synonyms: RARECHEM AK ML 0204;PYRIDIN-4-YL-ACETONITRILE;2-(Pyridin-4-yl)acetonitrile;Pyridine-4-yl-Acetonitrile;4-Pyridineacetonitrile;4-Pyridineacetonitrile, 97+%;2-(Pyridin-4-yl)
• CAS NO: 13121-99-8
• Molecular Formula: C₇H₆N₂
• Molecular Weight: 118.14
• Mol File: 13121-99-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 52-53 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 258.8°C at 760 mmHg
• Flash Point: 99.3°C
• Appearance: /Solid
• Density: 1.085g/cm³
• Vapor Pressure: 0.0135mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.49±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: PYRIDIN-4-YL-ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDIN-4-YL-ACETONITRILE(13121-99-8)
• EPA Substance Registry System: PYRIDIN-4-YL-ACETONITRILE(13121-99-8)

Safety Data

• HazardClass: 6.1
• Hazardous Substances Data: 13121-99-8(Hazardous Substances Data)

Usage

Description

PYRIDIN-4-YL-ACETONITRILE is a pyridine derivative characterized by its unique chemical structure, which features a nitrile group attached to a pyridine ring. PYRIDIN-4-YL-ACETONITRILE is known for its potential applications in various fields due to its distinct chemical properties.

Uses

Used in Pharmaceutical Industry:
PYRIDIN-4-YL-ACETONITRILE is used as a key intermediate compound for the synthesis of various pharmaceutical agents. Its unique structure allows it to be a versatile building block in the development of new drugs.
Used in Biochemical Research:
In the field of biochemistry, PYRIDIN-4-YL-ACETONITRILE serves as a valuable research tool. It is used in the preparation of inhibitors targeting Acyl CoA and cholesterol acyltransferase, which are essential enzymes involved in lipid metabolism. By inhibiting these enzymes, researchers can study their roles in various biological processes and develop potential therapeutic strategies for related diseases.
Used in Bone Morphogenetic Protein (BMP) Signaling Inhibition:
PYRIDIN-4-YL-ACETONITRILE is also utilized in the development of inhibitors for BMP signaling pathways. BMPs are a family of growth factors that play crucial roles in cell differentiation, proliferation, and tissue repair. Modulating BMP signaling can have significant implications in regenerative medicine and the treatment of various diseases, including bone disorders and certain types of cancer.

InChI:InChI=1/C7H6N2/c8-4-1-7-2-5-9-6-3-7/h2-3,5-6H,1H2

Upstream product

• 626-55-1 3-Bromopyridine 
• 75-05-8 acetonitrile 

Downstream Products

• 5451-38-7 Pyridyl-(4)-essigsaeure-thioamid 
• 54401-85-3 pyridin-4-yl-acetic acid ethyl ester 
• 96129-34-9 3-Phenyl-4-pyridin-4-yl-isoxazol-5-ylamine 
• 22433-65-4 4-Amino-5-(4-pyridyl)-pyrimidin 
• 157650-19-6 3-Amino-2-(4-pyridyl)propennitril 
• 216661-87-9 5-amino-4-(pyridin-4-yl)-1H-pyrazole 
• 216661-58-4 3-(pyridin-4-yl)-6-(4-methoxyphenyl)-pyrazolo(1,5-A)pyrimidine 
• 103284-44-2 3-butyl-3-(4-pyridyl)piperidine-2,6-dione 
• 103284-30-6 3-ethyl-1-octyl-3-(4-pyridyl)piperidine-2,6-dione 
• 103284-48-6 3-octyl-3-(4-pyrido)piperidine-2,6-dione 
• 55-22-1 pyridine-4-carboxylic acid 
• 680973-08-4 (2-amino-1-cyclopropyl-1-pyridin-4-yl)ethyl 
• 518354-96-6 C₁₅H₁₃FN₄O 
• 518354-96-6 C₁₅H₁₃FN₄O 

Relevant articles and documents

NEW APPLICATION OF COMPLEX BASES: NUCLEOPHILIC CONDENSATIONS OF PYRIDINE

3,4-Dehydropyridine can be easily generated from 3-bromopyridine by complex bases.Nucleophilic condensations of amines, ketones and nitrile enolates are thus performed for the first time in good to very good yields.