1312478-63-9

Basic information

• Product Name: 4-pyrazolyl-benzene boronic ester
• Synonyms: 4-pyrazolyl-benzene boronic ester;4-Pyrazol-1-yl-phenylboronic acid pinacol ester;1H-Pyrazole, 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
• CAS NO: 1312478-63-9
• Molecular Formula: C₁₅H₁₉BN₂O₂
• Molecular Weight: 270.13456
• Mol File: 1312478-63-9.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-pyrazolyl-benzene boronic ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-pyrazolyl-benzene boronic ester(1312478-63-9)
• EPA Substance Registry System: 4-pyrazolyl-benzene boronic ester(1312478-63-9)

Safety Data

• Hazardous Substances Data: 1312478-63-9(Hazardous Substances Data)

Usage

Description

4-pyrazolyl-benzene boronic ester is a chemical compound that belongs to the group of boronic esters, characterized by a benzene ring with a pyrazolyl group attached and a boronic ester functional group. It is a versatile reagent in organic synthesis and a valuable building block for the development of pharmaceuticals and agrochemicals.

Uses

Used in Organic Synthesis:
4-pyrazolyl-benzene boronic ester is used as a reagent in Suzuki-Miyaura coupling reactions for the formation of carbon-carbon bonds, a widely used method in organic chemistry to create complex molecules.
Used in Pharmaceutical Development:
4-pyrazolyl-benzene boronic ester is used as a building block in the synthesis of diverse biologically active compounds, contributing to the development of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Development:
4-pyrazolyl-benzene boronic ester is also utilized in the creation of agrochemicals, serving as a key component in the synthesis of compounds with pesticidal or herbicidal properties, enhancing crop protection and yield.

Upstream product

• 13788-92-6 1-(4-bromophenyl)-1H-pyrazole 
• 73183-34-3 bis(pinacol)diborane 
• 81329-32-0 1-(4-fluorophenyl)-1H-pyrazole 
• 352-34-1 4-fluoro-1-iodobenzene 
• 572912-93-7 1-[4-(methylthio)phenyl]pyrazole 
• 98581-87-4 C₉H₈N₂S 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 1312478-64-0 (2R)-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[4-(1H-pyrazol-1-yl)phenyl]pyridin-1(2H)-yl}-N-(tetrahydro-2H-pyran-2-yloxy)butanamide 
• 1312473-38-3 (2R)-N-hydroxy-2-methyl-2-(methylsulfonyl)-4-{2-oxo-4-[4-(1H-pyrazol-1-yl)phenyl]pyridin-1(2H)-yl}butanamide 

Relevant articles and documents

Copper-Catalyzed ipso-Borylation of Fluoroarenes

ipso-Borylation of fluoroarenes has been achieved using an air-stable copper complex as a catalyst. Mechanistic studies suggest that the reaction proceeds via an SRN1 mechanism involving a single-electron-transfer (SET) process and not via the typical SNAr mechanism. This method differs from the previously reported nickel/copper-cocatalyzed system in terms of scope of the substrate and has exhibited good scalability. Double and triple ipso-borylations of several di- and trifluoroarenes have been also achieved efficiently, enhancing the synthetic utility of this method.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as a medicament such as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof. wherein each symbol is as described in the attached DESCRIPTION.