131266-91-6Relevant articles and documents
Design, synthesis, biological evaluation and in silico study of benzyloxybenzaldehyde derivatives as selective aldh1a3 inhibitors
Ibrahim, Ali I. M.,Ikhmais, Balqis,Batlle, Elisabet,Abuharb, Waed K.,Jha, Vibhu,Jaradat, Khaled T.,Jiménez, Rafael,Pequerul, Raquel,Parés, Xavier,Farrés, Jaume,Pors, Klaus
, (2021/09/28)
Aldehyde dehydrogenase 1A3 (ALDH1A3) has recently gained attention from researchers in the cancer field. Several studies have reported ALDH1A3 overexpression in different cancer types, which has been found to correlate with poor treatment recovery. Theref
Aminolysis of Y-substituted phenyl X-substituted benzoates with piperidine: Effect of nonleaving group substituent
Um, Ik-Hwan,Lee, Ji-Youn,Ko, Seung-Hak,Bae, Sun-Kun
, p. 5800 - 5803 (2007/10/03)
The title reaction has been suggested to proceed through a zwitterionic tetrahedral intermediate with a change in the rate determining step on the basis of the curved Bronsted-type plots obtained. The curvature center of the curved Bronsted-type plots is at pKa = 6.4 regardless of the electronic nature of the substituent X in the benzoyl moiety.