1312679-75-6

Basic information

• Product Name: 5-bromo-2-{[(2E)-3-(2-bromophenyl)prop-2-enoyl]amino}benzamide
• Synonyms: 5-bromo-2-{[(2E)-3-(2-bromophenyl)prop-2-enoyl]amino}benzamide
• CAS NO: 1312679-75-6
• Molecular Weight: 424.091
• Mol File: 1312679-75-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-{[(2E)-3-(2-bromophenyl)prop-2-enoyl]amino}benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-{[(2E)-3-(2-bromophenyl)prop-2-enoyl]amino}benzamide(1312679-75-6)
• EPA Substance Registry System: 5-bromo-2-{[(2E)-3-(2-bromophenyl)prop-2-enoyl]amino}benzamide(1312679-75-6)

Safety Data

• Hazardous Substances Data: 1312679-75-6(Hazardous Substances Data)

Upstream product

• 4692-98-2 5-bromoisatoic anhydride 
• 7345-79-1 2-bromocinnamic acid 
• 16313-66-9 5-bromoanthranilamide 
• 851664-10-3 (E)-3-(2-bromophenyl)acryloyl chloride 

Relevant articles and documents

Synthesis, antiproliferative activity, and mechanism of action of a series of 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides

Several new 2-{[(2E)-3-phenylprop-2-enoyl]amino}benzamides 12a-s and 17t-v were synthesized by stirring in pyridine the (E)-3-(2-R1-3-R2-4-R3-phenyl) acrylic acid chlorides 11c-k and 11t-v with the appropriate anthranilamide derivatives 10a-c or the 5-iodoanthranilic acid 13. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against the full NCI tumor cell line panel derived from nine clinically isolated cancer types (leukemia, non-small cell lung, colon, CNS, melanoma, ovarian, renal, prostate and breast). COMPARE analysis, effects on tubulin polymerization in cells and with purified tubulin, and effects on cell cycle distribution for 17t, the most active of the series, indicate that these new antiproliferative compounds act as antitubulin agents.