1312681-83-6

Basic information

• Product Name: Z-Gly-Gly-L-Val-Pro-Gly-Gly-NH₂
• CAS NO: 1312681-83-6
• Molecular Weight: 575.622
• Mol File: 1312681-83-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Z-Gly-Gly-L-Val-Pro-Gly-Gly-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Gly-Gly-L-Val-Pro-Gly-Gly-NH₂(1312681-83-6)
• EPA Substance Registry System: Z-Gly-Gly-L-Val-Pro-Gly-Gly-NH₂(1312681-83-6)

Safety Data

• Hazardous Substances Data: 1312681-83-6(Hazardous Substances Data)

Upstream product

• 34152-86-8 Z-Gly-Gly-Val-OH 

Relevant articles and documents

PyOxP and PyOxB: The Oxyma-based novel family of phosphonium salts

Recent studies described the great impact of a non-benzotriazolic family of coupling reagents based on ethyl 2-cyano-2-(hydroxyimino)acetate, Oxyma, as a powerful coupling methodology for peptide synthesis. Here we present the synthesis and evaluation of the derived phosphonium salts O-[(1-cyano-2-ethoxy- 2-oxoethylidene)amino]-oxytri(pyrrolidin-1-yl) phosphonium hexafluorophosphate (PyOxP) and tetrafluoroborate (PyOxB). Both coupling reagents exhibited higher capacity to suppress racemization in various peptide models and enhanced solubility in DMF and DCM than benzotriazole-based reagents. In addition, the hexafluorophosphate analog PyOxP, combined excellent stability with outstanding efficiency in the assembly of demanding penta and decapeptides that include consecutive Aib residues. Cyclization models revealed the advantages of PyOxP, which rendered a higher percentage of cyclic material than other known potent phosphonium salts.