1312793-92-2

Basic information

• Product Name: 3-(3-ethoxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole
• Synonyms: 3-(3-ethoxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole
• CAS NO: 1312793-92-2
• Molecular Weight: 303.361
• Mol File: 1312793-92-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(3-ethoxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-ethoxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole(1312793-92-2)
• EPA Substance Registry System: 3-(3-ethoxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole(1312793-92-2)

Safety Data

• Hazardous Substances Data: 1312793-92-2(Hazardous Substances Data)

Upstream product

• 52805-46-6 2-methoxy-5-cyanophenol 
• 621-59-0 isovanillin 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 60758-86-3 3-ethoxy-4-methoxybenzenecarbonitrile 
• 1312793-85-3 tert-butyl 4-(3-(3-ethoxy-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate 
• 885957-47-1 C₁₀H₁₄N₂O₃ 

Relevant articles and documents

Design and Synthesis of 3,5-Disubstituted-1,2,4-Oxadiazoles as Potent Inhibitors of Phosphodiesterase4B2

A series of 3,5-disubstituted-1,2,4-oxadiazoles has been prepared and evaluated for phosphodiesterase inhibition (PDE4B2). Among the prepared 3,5-disubstituted-1,2,4-oxadiazoles, compound 9a is the most potent inhibitor (PDE4B2 IC50=5.28μm). Structure-activity relationship studies of 3,5-disubstituted-1,2,4-oxadiazoles revealed that substituents 3-cyclopentyloxy-4-methoxyphenyl group at 3-position and cyclic ring bearing heteroatoms at 5-position are important for activity. Molecular modeling study of the 3,5-disubstituted-1,2,4-oxadiazoles with PDE4B has shown similar interactions of 3-cyclopentyloxy-4-methoxyphenyl group; however, heteroatom ring is slightly deviating when compared to Piclamilast. 3-(3-Cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole (9a) exhibited good analgesic and antiinflammatory activities in formalin-induced pain in mice and carrageenan-induced paw edema model in rat.