1312806-27-1

Basic information

• Product Name: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-[11C]methylpiperidin-4-yl)methoxy)quinazolin-4-amine
• Synonyms: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-[11C]methylpiperidin-4-yl)methoxy)quinazolin-4-amine
• CAS NO: 1312806-27-1
• Molecular Weight: 474.35
• Mol File: 1312806-27-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-[11C]methylpiperidin-4-yl)methoxy)quinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-[11C]methylpiperidin-4-yl)methoxy)quinazolin-4-amine(1312806-27-1)
• EPA Substance Registry System: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-[11C]methylpiperidin-4-yl)methoxy)quinazolin-4-amine(1312806-27-1)

Safety Data

• Hazardous Substances Data: 1312806-27-1(Hazardous Substances Data)

Upstream product

• 145577-00-0 [11C]methyl triflate 
• 338992-12-4 N-Desmethylvandetanib 

Relevant articles and documents

Radiosynthesis of [11C]Vandetanib and [11C]chloro- Vandetanib as new potential PET agents for imaging of VEGFR in cancer

Vandetanib (ZD6474) and its chlorine analogue chloro-Vandetanib are potent and selective vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors with low nanomolar IC50 values. [ 11C]Vandetanib and [11C]chloro-Vandetanib, new potential PET agents for imaging of VEGFR in cancer, were first designed, synthesized and labeled at nitrogen and oxygen positions from their corresponding N- and O-des-methylated precursors, in 40-50% decay corrected radiochemical yield and 370-555 GBq/μmol specific activity at end of bombardment (EOB).