13129-69-6

Basic information

• Product Name: 1-(piperidin-1-ylmethyl)-1H-indole-2,3-dione
• Synonyms: 1-(Piperidin-1-ylmethyl)-1H-indole-2,3-dione; 1H-Indole-2,3-dione, 1-(1-piperidinylmethyl)-; 1-Piperidin-1-ylmethyl-1H-indole-2,3-dione
• CAS NO: 13129-69-6
• Molecular Formula: C₁₄H₁₆N₂O₂
• Molecular Weight: 244.289
• Mol File: 13129-69-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 391.9°C at 760 mmHg
• Flash Point: 175.4°C
• Density: 1.261g/cm³
• Vapor Pressure: 2.38E-06mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 1-(piperidin-1-ylmethyl)-1H-indole-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(piperidin-1-ylmethyl)-1H-indole-2,3-dione(13129-69-6)
• EPA Substance Registry System: 1-(piperidin-1-ylmethyl)-1H-indole-2,3-dione(13129-69-6)

Safety Data

• Hazardous Substances Data: 13129-69-6(Hazardous Substances Data)

Usage

Classification

Synthetic cathinone and psychoactive designer drug

Potency

Potent stimulant

Health effects

Associated with serious health effects such as psychosis, agitation, and seizures

Physical appearance

Often sold as a white or off-white crystalline powder

Recreational use

Typically used for its euphoric effects

Legal status

Classified as a Schedule I controlled substance in the United States

Legal restrictions

Illegal to manufacture, distribute, or possess without a license

Potential for abuse

High potential for abuse

Adverse health effects

Can cause significant harm to users

Importance of awareness

It is crucial to be aware of the dangers associated with the use of α-PVP due to its potential for abuse and adverse health effects.

Upstream product

• 110-89-4 piperidine 
• 50-00-0 formaldehyd 
• 91-56-5 indole-2,3-dione 

Relevant articles and documents

Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase

The effects of isatin Mannich bases incorporating (1-[piperidin-1-yl (P1)/morpholin-4-yl (P2)/N-methylpiperazin-1-yl (P3)]methyl)-1H-indole-2,3-dione) moieties against human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoenzymes hCA I and hCA II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes were evaluated. P1–P3 demonstrated impressive inhibition profiles against AChE and BChE and also inhibited both CAs at nanomolar level. These inhibitory effects were more powerful in all cases than the reference compounds used for all these enzymes. This study suggests that isatin Mannich bases P1–P3 are good candidate compounds especially for the development of new cholinesterase inhibitors since they were 2.2–5.9 times better inhibitors than clinically used drug Tacrine.

Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents

A series of new isatin-thiazoline 3a-h and isatin-benzimidazole 4a-h derivatives were synthesized via condensation of isatin Mannich bases 2a-h with either 2-aminothiazoline or 2-aminobenzimidazole. The structures of the newly synthesized compounds were c

Reactions of N chloromethyl isatin with prototropically active compounds. XIX

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