1312937-40-8

Basic information

• Product Name: 4-methoxyquinazoline-6,7-diol
• Synonyms: 4-methoxyquinazoline-6,7-diol
• CAS NO: 1312937-40-8
• Molecular Weight: 192.174
• Mol File: 1312937-40-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-methoxyquinazoline-6,7-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxyquinazoline-6,7-diol(1312937-40-8)
• EPA Substance Registry System: 4-methoxyquinazoline-6,7-diol(1312937-40-8)

Safety Data

• Hazardous Substances Data: 1312937-40-8(Hazardous Substances Data)

Upstream product

• 4101-33-1 6,7-dimethoxy-N,N-quinazoline 
• 67-56-1 methanol 
• 16064-15-6 6,7-dihydroxyquinazolin-4(3H)-one 

Downstream Products

• 1312937-41-9 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline 
• 183321-74-6 erlotinib 
• 183319-69-9 erlotinib hydrochloride 

Relevant articles and documents

PREPARATION PROCESS OF ERLOTINIB

Preparation process of erlotinib or its salts comprising: reacting 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline with 3-ethynylaniline or a salt thereof in the presence of a base and a reaction-inert solvent, and optionally, treating the compound obtained with a pharmaceutically acceptable acid to form the corresponding pharmaceutically acceptable salt. The compound 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline can be prepared either from 4-methoxyquinazoline-6,7-diol or 6,7-bis(2-methoxyethoxy)quinazolinone. The compounds 6,7-bis(2-methoxyethoxy)-4-methoxyquinazoline and 4-methoxyquinazoline-6,7-diol are new intermediates useful for the preparation of erlotinib or its salts.