131294-12-7

Basic information

• Product Name: ethyl [(3R)-(tert-butyldimethylsilyloxy)-3-phenyl]propionate
• Synonyms: ethyl [(3R)-(tert-butyldimethylsilyloxy)-3-phenyl]propionate
• CAS NO: 131294-12-7
• Molecular Weight: 308.493
• Mol File: 131294-12-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl [(3R)-(tert-butyldimethylsilyloxy)-3-phenyl]propionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl [(3R)-(tert-butyldimethylsilyloxy)-3-phenyl]propionate(131294-12-7)
• EPA Substance Registry System: ethyl [(3R)-(tert-butyldimethylsilyloxy)-3-phenyl]propionate(131294-12-7)

Safety Data

• Hazardous Substances Data: 131294-12-7(Hazardous Substances Data)

Upstream product

• 1118755-09-1 (S)-ethyl 3-(tert-butyldimethylsilyloxy)-2-diazo-3-phenylpropanoate 
• 72656-47-4 ethyl (R)-3-hydroxy-3-phenylpropanoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 941575-64-0 N-[(3R)-tert-butyldimethylsilyloxy-3-phenylpropionyl]-N-methyl-4-methylbenzenesulfonamide 
• 141-52-6 sodium ethanolate 

Downstream Products

• 351458-83-8 3-(tert-butyl-dimethyl-silanyloxy)-1-(2-hydroxy-phenyl)-3-phenyl-propan-1-one 
• 351458-84-9 (R)-3-Hydroxy-1-(2-hydroxy-phenyl)-3-phenyl-propan-1-one 
• 487-26-3 (2S)-flavanone 
• 888-12-0 (E)-2'-hydroxy-chalcone 
• 1036-72-2 Pinocembrin dimethyl ether 
• 480-37-5 pinostrobin 
• 351458-87-2 (R)-1-[2,4-dimethoxy-6-(methoxymethoxy)phenyl]-3-phenyl-3-(tert-butyldimethylsilyl)oxy-propan-1-one 
• 862254-91-9 (R)-3-hydroxy-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenylpropan-1-one 
• 351458-82-7 (R)-3-(tert-butyldimethylsylil)oxy-N-methoxy-N-methyl-benzenepropanamide 

Relevant articles and documents

Magnesium-catalyzed asymmetric direct aldol addition of ethyl diazoacetate to aromatic, aliphatic, and α,β-unsaturated aldehydes

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Inter- and intramolecular Mitsunobu reaction based approaches to 2-substituted chromans and chroman-4-ones

Two approaches to optically active 2-substituted chromans and chroman-4-ones are described. The first utilized an intermolecular Mitsunobu reaction of a homochiral halopropanol and 2-bromophenol followed by cyclization to the 2-substituted chroman. In addition, a double lithiation procedure was developed to introduce additional functionality to the chroman. The second approach utilized an intramolecular Mitsunobu cyclization to give the 2-substituted chroman-4-one nucleus. The methodologies were applied to the syntheses of several biologically active natural and synthetic products.