1313026-17-3Relevant articles and documents
Synthesis of 2-BMIDA 6,5-bicyclic heterocycles by Cu(i)/Pd(0)/Cu(II) cascade catalysis of 2-iodoaniline/phenols
Seath, Ciaran P.,Wilson, Kirsty L.,Campbell, Angus,Mowat, Jenna M.,Watson, Allan J.B.
supporting information, p. 8703 - 8706 (2016/07/15)
A one-pot cascade reaction for the synthesis of 2-BMIDA 6,5-bicyclic heterocycles has been developed using Cu(i)/Pd(0)/Cu(ii) catalysis. 2-Iodoanilines and phenols undergo a Cu(i)/Pd(0)-catalyzed Sonogashira reaction with ethynyl BMIDA followed by in situ Cu(ii)-catalyzed 5-endo-dig cyclization to generate heterocyclic scaffolds with a BMIDA functional group in the 2-position. The method provides efficient access to borylated indoles, benzofurans, and aza-derivatives, which can be difficult to access through alternative methods.
Tandem cycloisomerization/Suzuki coupling of arylethynyl MIDA boronates
Chan, Julian M.W.,Amarante, Giovanni W.,Toste, F. Dean
, p. 4306 - 4312 (2011/07/29)
A tandem gold-catalyzed cycloisomerization/Suzuki cross-coupling sequence involving arylethynyl-N-methyliminodiacetic acid boronates is described. Combining the mildness of homogeneous gold catalysis with the versatility of N-methyliminodiacetic acid (MID
